TY - JOUR
T1 - Molecular epidemiology of primary human cytomegalovirus infection in pregnant women and their families
AU - Revello, Maria Grazia
AU - Campanini, Giulia
AU - Piralla, Antonio
AU - Furione, Milena
AU - Percivalle, Elena
AU - Zavattoni, Maurizio
AU - Gerna, Giuseppe
PY - 2008/8
Y1 - 2008/8
N2 - The source of human cytomegalovirus (HCMV) infection was investigated in 29 pregnant women with primary HCMV infection by comparing DNA sequences of UL146, UL144 and a portion of UL55 gene of HCMV strains circulating within each family. Thirteen families were identified in which the pregnant woman, the husband and/ora child were shedding HCMV. In three of these families, both the woman and the husband suffered from a concomitant primary HCMV infection. Phylogenetic analysis of UL146, UL144, and UL55 genes indicated that strains circulating within each family were identical, whereas strains from different families appeared to be distinct. However, identical UL146, UL144, and UL55 DNA sequences were observed sporadically among unrelated strains. A child rather than the husband was the virus source for the great majority of pregnant women. No association was observed between UL144 polymorphisms and intrauterine transmission.
AB - The source of human cytomegalovirus (HCMV) infection was investigated in 29 pregnant women with primary HCMV infection by comparing DNA sequences of UL146, UL144 and a portion of UL55 gene of HCMV strains circulating within each family. Thirteen families were identified in which the pregnant woman, the husband and/ora child were shedding HCMV. In three of these families, both the woman and the husband suffered from a concomitant primary HCMV infection. Phylogenetic analysis of UL146, UL144, and UL55 genes indicated that strains circulating within each family were identical, whereas strains from different families appeared to be distinct. However, identical UL146, UL144, and UL55 DNA sequences were observed sporadically among unrelated strains. A child rather than the husband was the virus source for the great majority of pregnant women. No association was observed between UL144 polymorphisms and intrauterine transmission.
KW - HCMV
KW - Molecular epidemiology
KW - Pregnancy
KW - UL144
KW - UL146
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U2 - 10.1002/jmv.21243
DO - 10.1002/jmv.21243
M3 - Article
C2 - 18551604
AN - SCOPUS:46049100572
VL - 80
SP - 1415
EP - 1425
JO - Journal of Medical Virology
JF - Journal of Medical Virology
SN - 0146-6615
IS - 8
ER -