Molecular fingerprints of environmental carcinogens in human cancer

C. Ceccaroli, A. Pulliero, M. Geretto, A. Izzotti

Research output: Contribution to journalArticle

Abstract

Identification of specific molecular changes (fingerprints) is important to identify cancer etiology. Exploitable biomarkers are related to DNA, epigenetics, and proteins. DNA adducts are the turning point between environmental exposures and biological damage. DNA mutational fingerprints are induced by carcinogens in tumor suppressor and oncogenes. In an epigenetic domain, methylation changes occurs in specific genes for arsenic, benzene, chromium, and cigarette smoke. Alteration of specific microRNA has been reported for environmental carcinogens. Benzo(a)pyrene, cadmium, coal, and wood dust hits specific heat-shock proteins and metalloproteases. The multiple analysis of these biomarkers provides information on the carcinogenic mechanisms activated by exposure to environmental carcinogens.

Original languageEnglish
Pages (from-to)188-228
Number of pages41
JournalJournal of Environmental Science and Health - Part C Environmental Carcinogenesis and Ecotoxicology Reviews
Volume33
Issue number2
DOIs
Publication statusPublished - Apr 3 2015

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Keywords

  • environmental carcinogens
  • human cancer
  • molecular biomarkers

ASJC Scopus subject areas

  • Health, Toxicology and Mutagenesis
  • Cancer Research

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