Molecular genetic characterization of the 11q13 breakpoint in a desmoplastic fibroma of bone

Domenico Trombetta, Gemma Macchia, Nils Mandahl, Karolin H. Nord, Fredrik Mertens

Research output: Contribution to journalArticlepeer-review

Abstract

Desmoplastic fibroma (DFB) is a benign primary bone tumor that usually occurs in adolescents and young adults. The genetic information on DFB is very limited. We here present cytogenetic, fluorescence in situ hybridization and single nucleotide polymorphism array findings in a case that had a rearrangement involving chromosomes 11 and 19 at G-banding analysis. The results showed that the breakpoint in 11q was different from that in desmoplastic fibroblastomas, and a segment containing five genes was hemizygously deleted from 11q13.

Original languageEnglish
Pages (from-to)410-413
Number of pages4
JournalCancer genetics
Volume205
Issue number7-8
DOIs
Publication statusPublished - Jul 2012

Keywords

  • 11q13
  • Desmoplastic fibroblastoma
  • Desmoplastic fibroma
  • FISH
  • SNP array

ASJC Scopus subject areas

  • Cancer Research
  • Genetics
  • Molecular Biology

Fingerprint

Dive into the research topics of 'Molecular genetic characterization of the 11q13 breakpoint in a desmoplastic fibroma of bone'. Together they form a unique fingerprint.

Cite this