Molecular genetics of acute myeloid leukemia

Paolo Bernasconi, Marina Boni, Paola Maria Cavigliano, Silvia Calatroni, Ilaria Giardini, Barbara Rocca, Marilena Caresana

Research output: Contribution to journalArticlepeer-review

Abstract

Recurring chromosomal abnormalities are detected in most patients with acute myeloid leukemia (AML). They may be associated with a distinct AML FAB subtype or may identify distinct clinicobiological entities within the same FAB subtype. Therefore, cytogenetic investigation has a pivotal role in AML diagnosis. In addition, it is one of the most valuable prognostic determinants of the disease, as recently demonstrated. The development of new molecular techniques, such as reverse transcriptase polymerase chain reaction and fluorescence in situ hybridization, has allowed perfect definition of the chromosome regions containing genes with a crucial role in normal hemopoiesis and leukemia. Understanding the action of such genes provides new insights into AML pathogenesis and has led us to envisage new therapeutic options.

Original languageEnglish
Pages (from-to)297-305
Number of pages9
JournalAnnals of the New York Academy of Sciences
Volume963
Publication statusPublished - 2002

Keywords

  • Acute myeloid leukemia
  • Chromosomal abnormalities
  • FAB subtype
  • Genetics

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

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