Abstract
Recurring chromosomal abnormalities are detected in most patients with acute myeloid leukemia (AML). They may be associated with a distinct AML FAB subtype or may identify distinct clinicobiological entities within the same FAB subtype. Therefore, cytogenetic investigation has a pivotal role in AML diagnosis. In addition, it is one of the most valuable prognostic determinants of the disease, as recently demonstrated. The development of new molecular techniques, such as reverse transcriptase polymerase chain reaction and fluorescence in situ hybridization, has allowed perfect definition of the chromosome regions containing genes with a crucial role in normal hemopoiesis and leukemia. Understanding the action of such genes provides new insights into AML pathogenesis and has led us to envisage new therapeutic options.
| Original language | English |
|---|---|
| Pages (from-to) | 297-305 |
| Number of pages | 9 |
| Journal | Annals of the New York Academy of Sciences |
| Volume | 963 |
| Publication status | Published - 2002 |
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Keywords
- Acute myeloid leukemia
- Chromosomal abnormalities
- FAB subtype
- Genetics
ASJC Scopus subject areas
- Biochemistry, Genetics and Molecular Biology(all)
Cite this
Molecular genetics of acute myeloid leukemia. / Bernasconi, Paolo; Boni, Marina; Cavigliano, Paola Maria; Calatroni, Silvia; Giardini, Ilaria; Rocca, Barbara; Caresana, Marilena.
In: Annals of the New York Academy of Sciences, Vol. 963, 2002, p. 297-305.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Molecular genetics of acute myeloid leukemia
AU - Bernasconi, Paolo
AU - Boni, Marina
AU - Cavigliano, Paola Maria
AU - Calatroni, Silvia
AU - Giardini, Ilaria
AU - Rocca, Barbara
AU - Caresana, Marilena
PY - 2002
Y1 - 2002
N2 - Recurring chromosomal abnormalities are detected in most patients with acute myeloid leukemia (AML). They may be associated with a distinct AML FAB subtype or may identify distinct clinicobiological entities within the same FAB subtype. Therefore, cytogenetic investigation has a pivotal role in AML diagnosis. In addition, it is one of the most valuable prognostic determinants of the disease, as recently demonstrated. The development of new molecular techniques, such as reverse transcriptase polymerase chain reaction and fluorescence in situ hybridization, has allowed perfect definition of the chromosome regions containing genes with a crucial role in normal hemopoiesis and leukemia. Understanding the action of such genes provides new insights into AML pathogenesis and has led us to envisage new therapeutic options.
AB - Recurring chromosomal abnormalities are detected in most patients with acute myeloid leukemia (AML). They may be associated with a distinct AML FAB subtype or may identify distinct clinicobiological entities within the same FAB subtype. Therefore, cytogenetic investigation has a pivotal role in AML diagnosis. In addition, it is one of the most valuable prognostic determinants of the disease, as recently demonstrated. The development of new molecular techniques, such as reverse transcriptase polymerase chain reaction and fluorescence in situ hybridization, has allowed perfect definition of the chromosome regions containing genes with a crucial role in normal hemopoiesis and leukemia. Understanding the action of such genes provides new insights into AML pathogenesis and has led us to envisage new therapeutic options.
KW - Acute myeloid leukemia
KW - Chromosomal abnormalities
KW - FAB subtype
KW - Genetics
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UR - http://www.scopus.com/inward/citedby.url?scp=0036291343&partnerID=8YFLogxK
M3 - Article
C2 - 12095955
AN - SCOPUS:0036291343
VL - 963
SP - 297
EP - 305
JO - Annals of the New York Academy of Sciences
JF - Annals of the New York Academy of Sciences
SN - 0077-8923
ER -