Molecular genetics of breast cancer

P. Radice, M. A. Pierotti

Research output: Contribution to journalArticlepeer-review

Abstract

In the last two decades, molecular studies have enlightened the complexity of the genetic alterations that occur in breast cancer cells. To date, more than 40 different genes or loci have been found to be altered in breast carcinomas. Although some of these genes, as for example ERBB2, appear to be mutated in a high proportion of cases, their mechanism of action and their role in the different stages of cancer development are still poorly understood. More recently, two major determinants of the inherited predisposition to breast cancer, BRCA1 and BRCA2, have been isolated. As a consequence, it is now possible to screen families with a positive history of breast carcinomas for the identification of mutations carriers, in order to address these individuals into adequate programs of cancer surveillance and prevention.

Original languageEnglish
Pages (from-to)189-199
Number of pages11
JournalQuarterly Journal of Nuclear Medicine
Volume41
Issue number3
Publication statusPublished - 1997

Keywords

  • Breast neoplasms genetics

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging

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