Molecular genetics of lymphoid tumorigenesis.

F. G. Haluska, Y. Tsujimoto, G. Russo, M. Isobe, C. M. Croce

Research output: Contribution to journalArticle

Abstract

The body of this work illustrates the utility of the combined cytogenetic and molecular approach to lymphoid tumorigenesis. A number of tumor-specific translocations have proven amenable to dissection by molecular techniques. We have a firm grasp of the general principles that underlie lymphoid neoplasia; in particular, the activation of cellular oncogenes by translocation into genes of the immunoglobulin superfamily is a widespread phenomenon. However, numerous lymphopoietic malignancies are only poorly understood. These remain a challenge for the continued application of these methodologies.

Original languageEnglish
Pages (from-to)269-280
Number of pages12
JournalProgress in Nucleic Acid Research and Molecular Biology
Volume36
Publication statusPublished - 1989

ASJC Scopus subject areas

  • Medicine(all)
  • Molecular Biology

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    Haluska, F. G., Tsujimoto, Y., Russo, G., Isobe, M., & Croce, C. M. (1989). Molecular genetics of lymphoid tumorigenesis. Progress in Nucleic Acid Research and Molecular Biology, 36, 269-280.