Molecular heterogeneity characterizes glioblastoma with lipoblast/adipocyte-like cytology

Marco Gessi, Gerrit H. Gielen, Dorota Denkhaus, Manila Antonelli, Felice Giangaspero, Anja zur Mühlen, Anna Sophia Japp, Torsten Pietsch

Research output: Contribution to journalArticlepeer-review

Abstract

Glioblastoma, the most common primary brain tumor in adults, may rarely show among unusual histological patterns lipoblast/adipocyte-like features. The genetic features of such cases are not yet well characterized, and molecular data are available for only few cases. In order to further expand our knowledge about their molecular profile, we analyzed four cases of glioblastoma with adipocyte-like features. Multiplex ligation-dependent probe amplification (MLPA) revealed loss of PTEN and MDM2 amplification in two cases while another case was characterized by CDKN2A deletion. Conversely, we did not find any evidence of EGFR amplification, BRAFV600E or IDH1/2 mutations. Our results, along with data published in previous studies, showed that glioblastoma with lipoblast/adipocyte-like cytology present a heterogeneous genetic background and therefore seem to represent more a rare phenotypic variant than a specific tumor subtype.

Original languageEnglish
Pages (from-to)105-109
Number of pages5
JournalVirchows Archiv
Volume467
Issue number1
DOIs
Publication statusPublished - Jul 1 2015

Keywords

  • CDKN2A
  • Glioblastomas with lipoblast/adipocyte-like cytology
  • Lipid-rich glioblastoma
  • MDM2
  • PTEN

ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Cell Biology
  • Molecular Biology
  • Medicine(all)

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