Molecular hydrogen enhances osteogenesis in Danio rerio embryos

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Molecular hydrogen (H2) has been reported to have important biological effects on bone tissue in several in vitro and in vivo models. Danio rerio (zebrafish) embryo is a good model to study osteogenesis because of its transparency, size and rapid development. In zebrafish embryo, hydrogen-rich water (HRW) does not affect vitality or growth rate up to 15%. In addition, 7% HRW treatment enhances zebrafish embryo osteogenesis, increasing the vertebral mineralization rate. In conclusion, we demonstrated the beneficial effects of hydrogen on anabolic bone functions in vivo.

Original languageEnglish
Pages (from-to)1471-1474
JournalJournal of Fish Biology
Issue number5
Publication statusPublished - 2021


  • bone
  • embryo
  • hydrogen
  • osteogenesis
  • zebrafish

ASJC Scopus subject areas

  • Ecology, Evolution, Behavior and Systematics
  • Aquatic Science


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