Molecular identification and antibody testing of Chlamydophila pneumoniae in a subgroup of patients with HIV-associated dementia complex. Preliminary results

Carlo Contini, Enrico Fainardi, Silva Seraceni, Enrico Granieri, Massimiliano Castellazzi, Rosario Cultrera

Research output: Contribution to journalArticle

Abstract

Chlamydophila pneumoniae DNA was investigated by polymerase chain reaction (PCR), in cerebrospinal fluid (CSF) specimens from patients suffering from HIV-1-associated dementia complex (HADC). Four (17.3%) cases of C. pneumoniae infection were identified among 23 HADC individuals with DNA amplification of major outer membrane protein (MOMP) gene and 16S rRNA gene sequences. Sequence analysis revealed significant homologies with C. pneumoniae compared to Chlamydia trachomatis and Chlamydia psittaci. High mean levels of CSF specific anti-C. pneumoniae antibodies and C. pneumoniae antibody specific index values significantly elevated were also found by enzyme-linked immunosorbent assay (ELISA) in these patients. The results suggest a hypothetical role of C. pneumoniae in the pathogenesis or progression of HADC.

Original languageEnglish
Pages (from-to)172-177
Number of pages6
JournalJournal of Neuroimmunology
Volume136
Issue number1-2
DOIs
Publication statusPublished - Mar 2003

Keywords

  • AIDS
  • Chlamydophila pneumoniae
  • CSF-PCR
  • ELISA
  • HIV-1-associated dementia complex

ASJC Scopus subject areas

  • Immunology
  • Clinical Neurology
  • Immunology and Allergy
  • Neurology

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