Molecular imaging: High-resolution detectors for early diagnosis and therapy monitoring of breast cancer

F. Garibaldi, E. Cisbani, S. Colilli, F. Cusanno, R. Fratoni, F. Giuliani, M. Gricia, M. Lucentini, R. Fratoni, S. Lo Meo, M. L. Magliozzi, F. Santanvenere, M. N. Cinti, R. Pani, R. Pellegrini, G. Simonetti, O. Schillaci, S. Del Vecchio, M. Salvatore, S. MajewskiR. C. Lanza, G. De Vincentis, F. Scopinaro

Research output: Contribution to journalArticle

Abstract

Dedicated high-resolution detectors are required for detection of small cancerous breast tumours by molecular imaging with radionuclides. Absorptive collimation is normally applied in imaging single photon emitters, but it results in a strong reduction in detection efficiency. Systems based on electronic collimation are complex and expensive. For these reasons simulations and measurements have been performed to design optimised dedicated high-resolution mini gamma camera. Critical parameters are contrast and signal-to-noise ratio (SNR). Intrinsic performance (spatial resolution, pixel identification, and response linearity and uniformity) were first optimised. Pixellated scintillator arrays (NaI(Tl)) of different pixel size were coupled to arrays of PSPMTs with different anode pad dimensions (6×6 mm2 and 3×3 mm2). Detectors having a field of view (FOV) of 100×100 mm2 and 150×200 mm2 were designed and built. The electronic system allows read out of all the anode pad signals. The collimation technique was then considered and limits of coded aperture option were studied. Preliminary results are presented.

Original languageEnglish
Pages (from-to)286-290
Number of pages5
JournalNuclear Instruments and Methods in Physics Research, Section A: Accelerators, Spectrometers, Detectors and Associated Equipment
Volume569
Issue number2 SPEC. ISS.
DOIs
Publication statusPublished - Dec 20 2006

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Keywords

  • Breast cancer
  • High-resolution molecular imaging
  • Radionuclides

ASJC Scopus subject areas

  • Instrumentation
  • Nuclear and High Energy Physics

Cite this

Garibaldi, F., Cisbani, E., Colilli, S., Cusanno, F., Fratoni, R., Giuliani, F., Gricia, M., Lucentini, M., Fratoni, R., Lo Meo, S., Magliozzi, M. L., Santanvenere, F., Cinti, M. N., Pani, R., Pellegrini, R., Simonetti, G., Schillaci, O., Del Vecchio, S., Salvatore, M., ... Scopinaro, F. (2006). Molecular imaging: High-resolution detectors for early diagnosis and therapy monitoring of breast cancer. Nuclear Instruments and Methods in Physics Research, Section A: Accelerators, Spectrometers, Detectors and Associated Equipment, 569(2 SPEC. ISS.), 286-290. https://doi.org/10.1016/j.nima.2006.08.098