Molecular imaging: High-resolution detectors for early diagnosis and therapy monitoring of breast cancer

F. Garibaldi; E. Cisbani; S. Colilli; F. Cusanno; R. Fratoni; F. Giuliani; M. Gricia; M. Lucentini; R. Fratoni; S. Lo Meo; M. L. Magliozzi; F. Santanvenere; M. N. Cinti; R. Pani; R. Pellegrini; G. Simonetti; O. Schillaci; S. Del Vecchio; M. Salvatore; S. Majewski; R. C. Lanza; G. De Vincentis; F. Scopinaro

doi:10.1016/j.nima.2006.08.098

Molecular imaging: High-resolution detectors for early diagnosis and therapy monitoring of breast cancer

F. Garibaldi, E. Cisbani, S. Colilli, F. Cusanno, R. Fratoni, F. Giuliani, M. Gricia, M. Lucentini, R. Fratoni, S. Lo Meo, M. L. Magliozzi, F. Santanvenere, M. N. Cinti, R. Pani, R. Pellegrini, G. Simonetti, O. Schillaci, S. Del Vecchio, M. Salvatore, S. MajewskiR. C. Lanza, G. De Vincentis, F. Scopinaro

Research output: Contribution to journal › Article › peer-review

Abstract

Dedicated high-resolution detectors are required for detection of small cancerous breast tumours by molecular imaging with radionuclides. Absorptive collimation is normally applied in imaging single photon emitters, but it results in a strong reduction in detection efficiency. Systems based on electronic collimation are complex and expensive. For these reasons simulations and measurements have been performed to design optimised dedicated high-resolution mini gamma camera. Critical parameters are contrast and signal-to-noise ratio (SNR). Intrinsic performance (spatial resolution, pixel identification, and response linearity and uniformity) were first optimised. Pixellated scintillator arrays (NaI(Tl)) of different pixel size were coupled to arrays of PSPMTs with different anode pad dimensions (6×6 mm² and 3×3 mm²). Detectors having a field of view (FOV) of 100×100 mm² and 150×200 mm² were designed and built. The electronic system allows read out of all the anode pad signals. The collimation technique was then considered and limits of coded aperture option were studied. Preliminary results are presented.

Original language	English
Pages (from-to)	286-290
Number of pages	5
Journal	Nuclear Instruments and Methods in Physics Research, Section A: Accelerators, Spectrometers, Detectors and Associated Equipment
Volume	569
Issue number	2 SPEC. ISS.
DOIs	https://doi.org/10.1016/j.nima.2006.08.098
Publication status	Published - Dec 20 2006

Keywords

Breast cancer
High-resolution molecular imaging
Radionuclides

ASJC Scopus subject areas

Instrumentation
Nuclear and High Energy Physics

Access to Document

10.1016/j.nima.2006.08.098

Cite this

Garibaldi, F., Cisbani, E., Colilli, S., Cusanno, F., Fratoni, R., Giuliani, F., Gricia, M., Lucentini, M., Fratoni, R., Lo Meo, S., Magliozzi, M. L., Santanvenere, F., Cinti, M. N., Pani, R., Pellegrini, R., Simonetti, G., Schillaci, O., Del Vecchio, S., Salvatore, M., ... Scopinaro, F. (2006). Molecular imaging: High-resolution detectors for early diagnosis and therapy monitoring of breast cancer. Nuclear Instruments and Methods in Physics Research, Section A: Accelerators, Spectrometers, Detectors and Associated Equipment, 569(2 SPEC. ISS.), 286-290. https://doi.org/10.1016/j.nima.2006.08.098

Molecular imaging : High-resolution detectors for early diagnosis and therapy monitoring of breast cancer. / Garibaldi, F.; Cisbani, E.; Colilli, S. et al.

In: Nuclear Instruments and Methods in Physics Research, Section A: Accelerators, Spectrometers, Detectors and Associated Equipment, Vol. 569, No. 2 SPEC. ISS., 20.12.2006, p. 286-290.

Research output: Contribution to journal › Article › peer-review

Garibaldi, F, Cisbani, E, Colilli, S, Cusanno, F, Fratoni, R, Giuliani, F, Gricia, M, Lucentini, M, Fratoni, R, Lo Meo, S, Magliozzi, ML, Santanvenere, F, Cinti, MN, Pani, R, Pellegrini, R, Simonetti, G, Schillaci, O, Del Vecchio, S, Salvatore, M, Majewski, S, Lanza, RC, De Vincentis, G & Scopinaro, F 2006, 'Molecular imaging: High-resolution detectors for early diagnosis and therapy monitoring of breast cancer', Nuclear Instruments and Methods in Physics Research, Section A: Accelerators, Spectrometers, Detectors and Associated Equipment, vol. 569, no. 2 SPEC. ISS., pp. 286-290. https://doi.org/10.1016/j.nima.2006.08.098

Garibaldi F, Cisbani E, Colilli S, Cusanno F, Fratoni R, Giuliani F et al. Molecular imaging: High-resolution detectors for early diagnosis and therapy monitoring of breast cancer. Nuclear Instruments and Methods in Physics Research, Section A: Accelerators, Spectrometers, Detectors and Associated Equipment. 2006 Dec 20;569(2 SPEC. ISS.):286-290. https://doi.org/10.1016/j.nima.2006.08.098

@article{06a46d7b040b4e608b8ed0e0743f727e,

title = "Molecular imaging: High-resolution detectors for early diagnosis and therapy monitoring of breast cancer",

abstract = "Dedicated high-resolution detectors are required for detection of small cancerous breast tumours by molecular imaging with radionuclides. Absorptive collimation is normally applied in imaging single photon emitters, but it results in a strong reduction in detection efficiency. Systems based on electronic collimation are complex and expensive. For these reasons simulations and measurements have been performed to design optimised dedicated high-resolution mini gamma camera. Critical parameters are contrast and signal-to-noise ratio (SNR). Intrinsic performance (spatial resolution, pixel identification, and response linearity and uniformity) were first optimised. Pixellated scintillator arrays (NaI(Tl)) of different pixel size were coupled to arrays of PSPMTs with different anode pad dimensions (6×6 mm2 and 3×3 mm2). Detectors having a field of view (FOV) of 100×100 mm2 and 150×200 mm2 were designed and built. The electronic system allows read out of all the anode pad signals. The collimation technique was then considered and limits of coded aperture option were studied. Preliminary results are presented.",

keywords = "Breast cancer, High-resolution molecular imaging, Radionuclides",

author = "F. Garibaldi and E. Cisbani and S. Colilli and F. Cusanno and R. Fratoni and F. Giuliani and M. Gricia and M. Lucentini and R. Fratoni and {Lo Meo}, S. and Magliozzi, {M. L.} and F. Santanvenere and Cinti, {M. N.} and R. Pani and R. Pellegrini and G. Simonetti and O. Schillaci and {Del Vecchio}, S. and M. Salvatore and S. Majewski and Lanza, {R. C.} and {De Vincentis}, G. and F. Scopinaro",

year = "2006",

month = dec,

day = "20",

doi = "10.1016/j.nima.2006.08.098",

language = "English",

volume = "569",

pages = "286--290",

journal = "Nuclear Instruments and Methods in Physics Research, Section A: Accelerators, Spectrometers, Detectors and Associated Equipment",

issn = "0168-9002",

publisher = "Elsevier",

number = "2 SPEC. ISS.",

}

TY - JOUR

T1 - Molecular imaging

T2 - High-resolution detectors for early diagnosis and therapy monitoring of breast cancer

AU - Garibaldi, F.

AU - Cisbani, E.

AU - Colilli, S.

AU - Cusanno, F.

AU - Fratoni, R.

AU - Giuliani, F.

AU - Gricia, M.

AU - Lucentini, M.

AU - Fratoni, R.

AU - Lo Meo, S.

AU - Magliozzi, M. L.

AU - Santanvenere, F.

AU - Cinti, M. N.

AU - Pani, R.

AU - Pellegrini, R.

AU - Simonetti, G.

AU - Schillaci, O.

AU - Del Vecchio, S.

AU - Salvatore, M.

AU - Majewski, S.

AU - Lanza, R. C.

AU - De Vincentis, G.

AU - Scopinaro, F.

PY - 2006/12/20

Y1 - 2006/12/20

N2 - Dedicated high-resolution detectors are required for detection of small cancerous breast tumours by molecular imaging with radionuclides. Absorptive collimation is normally applied in imaging single photon emitters, but it results in a strong reduction in detection efficiency. Systems based on electronic collimation are complex and expensive. For these reasons simulations and measurements have been performed to design optimised dedicated high-resolution mini gamma camera. Critical parameters are contrast and signal-to-noise ratio (SNR). Intrinsic performance (spatial resolution, pixel identification, and response linearity and uniformity) were first optimised. Pixellated scintillator arrays (NaI(Tl)) of different pixel size were coupled to arrays of PSPMTs with different anode pad dimensions (6×6 mm2 and 3×3 mm2). Detectors having a field of view (FOV) of 100×100 mm2 and 150×200 mm2 were designed and built. The electronic system allows read out of all the anode pad signals. The collimation technique was then considered and limits of coded aperture option were studied. Preliminary results are presented.

AB - Dedicated high-resolution detectors are required for detection of small cancerous breast tumours by molecular imaging with radionuclides. Absorptive collimation is normally applied in imaging single photon emitters, but it results in a strong reduction in detection efficiency. Systems based on electronic collimation are complex and expensive. For these reasons simulations and measurements have been performed to design optimised dedicated high-resolution mini gamma camera. Critical parameters are contrast and signal-to-noise ratio (SNR). Intrinsic performance (spatial resolution, pixel identification, and response linearity and uniformity) were first optimised. Pixellated scintillator arrays (NaI(Tl)) of different pixel size were coupled to arrays of PSPMTs with different anode pad dimensions (6×6 mm2 and 3×3 mm2). Detectors having a field of view (FOV) of 100×100 mm2 and 150×200 mm2 were designed and built. The electronic system allows read out of all the anode pad signals. The collimation technique was then considered and limits of coded aperture option were studied. Preliminary results are presented.

KW - Breast cancer

KW - High-resolution molecular imaging

KW - Radionuclides

UR - http://www.scopus.com/inward/record.url?scp=33751405786&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=33751405786&partnerID=8YFLogxK

U2 - 10.1016/j.nima.2006.08.098

DO - 10.1016/j.nima.2006.08.098

M3 - Article

AN - SCOPUS:33751405786

VL - 569

SP - 286

EP - 290

JO - Nuclear Instruments and Methods in Physics Research, Section A: Accelerators, Spectrometers, Detectors and Associated Equipment

JF - Nuclear Instruments and Methods in Physics Research, Section A: Accelerators, Spectrometers, Detectors and Associated Equipment

SN - 0168-9002

IS - 2 SPEC. ISS.

ER -

Molecular imaging: High-resolution detectors for early diagnosis and therapy monitoring of breast cancer

Abstract

Keywords

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this