Molecular imaging in radiotherapy planning for head and neck tumors

Vincent Grégoire, Arturo Chiti

Research output: Contribution to journalArticle

Abstract

Molecular imaging uses noninvasive techniques to visualize various biologic pathways and physiologic characteristics of tumors and normal tissues. In relation to radiation therapy, PET with the tracer 18F-FDG offers a unique opportunity to refine the target volume delineation in patients with squamous cell carcinoma of the head and neck, in turn affecting dose distribution and, it is hoped, patient outcome. Even more so, in the framework of adaptive treatment and theragnostics, whereby dose distribution is adapted in space and time over the typical course of radiotherapy, molecular imaging with PET offers an elegant research avenue to further improve the therapeutic ratio. Such implementation could be of particular interest with tracers other than 18F-FDG, such as tracers of hypoxia and proliferation.

Original languageEnglish
Pages (from-to)331-334
Number of pages4
JournalJournal of Nuclear Medicine
Volume52
Issue number3
DOIs
Publication statusPublished - Mar 1 2011

Keywords

  • Dose painting
  • FDG
  • PET
  • Radiotherapy
  • Target volume delineation

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging

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