Molecular imaging of atherosclerosis in translational medicine

Pasquale Perrone-Filardi, Santo Dellegrottaglie, James H F Rudd, Pierluigi Costanzo, Caterina Marciano, Enrico Vassallo, Fabio Marsico, Donatella Ruggiero, Maria Piera Petretta, Massimo Chiariello, Alberto Cuocolo

Research output: Contribution to journalArticlepeer-review

Abstract

Functional characterization of atherosclerosis is a promising application of molecular imaging. Radionuclide-based techniques for molecular imaging in the large arteries (e.g. aorta and carotids), along with ultrasound and magnetic resonance imaging (MRI), have been studied both experimentally and in clinical studies. Technical factors including cardiac and respiratory motion, low spatial resolution and partial volume effects mean that noninvasive molecular imaging of atherosclerosis in the coronary arteries is not ready for prime time. Positron emission tomography imaging with fluorodeoxyglucose can measure vascular inflammation in the large arteries with high reproducibility, and signal change in response to anti-inflammatory therapy has been described. MRI has proven of value for quantifying carotid artery inflammation when iron oxide nanoparticles are used as a contrast agent. Macrophage accumulation of the iron particles allows regression of inflammation to be measured with drug therapy. Similarly, contrast-enhanced ultrasound imaging is also being evaluated for functional characterization of atherosclerotic plaques. For all of these techniques, however, large-scale clinical trials are mandatory to define the prognostic importance of the imaging signals in terms of risk of future vascular events.

Original languageEnglish
Pages (from-to)969-975
Number of pages7
JournalEuropean Journal of Nuclear Medicine and Molecular Imaging
Volume38
Issue number5
DOIs
Publication statusPublished - May 2011

Keywords

  • Atherosclerosis
  • FDG PET
  • Molecular imaging
  • MRI
  • Ultrasound imaging

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging

Fingerprint

Dive into the research topics of 'Molecular imaging of atherosclerosis in translational medicine'. Together they form a unique fingerprint.

Cite this