TY - JOUR
T1 - Molecular imaging of cell-mediated cancer immunotherapy
AU - Lucignani, Giovanni
AU - Ottobrini, Luisa
AU - Martelli, Cristina
AU - Rescigno, Maria
AU - Clerici, Mario
PY - 2006/9
Y1 - 2006/9
N2 - New strategies based on the activation of a patient's immune response are being sought to complement present conventional exogenous cancer therapies. Elucidating the trafficking pathways of immune cells in vivo, together with their migratory properties in relation to their differentiation and activation status, is useful for understanding how the immune system interacts with cancer. Methods based on tissue sampling to monitor immune responses are inadequate for repeatedly characterizing the responses of the immune system in different organs. A solution to this problem might come from molecular and cellular imaging - a branch of biomedical sciences that combines biotechnology and imaging methods to characterize, in vivo, the molecular and cellular processes involved in normal and pathologic states. The general concepts of noninvasive imaging of targeted cells as well as the technology and probes applied to cell-mediated cancer immunotherapy imaging are outlined in this review.
AB - New strategies based on the activation of a patient's immune response are being sought to complement present conventional exogenous cancer therapies. Elucidating the trafficking pathways of immune cells in vivo, together with their migratory properties in relation to their differentiation and activation status, is useful for understanding how the immune system interacts with cancer. Methods based on tissue sampling to monitor immune responses are inadequate for repeatedly characterizing the responses of the immune system in different organs. A solution to this problem might come from molecular and cellular imaging - a branch of biomedical sciences that combines biotechnology and imaging methods to characterize, in vivo, the molecular and cellular processes involved in normal and pathologic states. The general concepts of noninvasive imaging of targeted cells as well as the technology and probes applied to cell-mediated cancer immunotherapy imaging are outlined in this review.
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U2 - 10.1016/j.tibtech.2006.07.003
DO - 10.1016/j.tibtech.2006.07.003
M3 - Article
C2 - 16870284
AN - SCOPUS:33747109783
VL - 24
SP - 410
EP - 418
JO - Trends in Biotechnology
JF - Trends in Biotechnology
SN - 0167-7799
IS - 9
ER -