Molecular imaging of neuroblastoma progression in TH-MYCN transgenic mice

Carmelo Quarta, Erika Cantelli, Cristina Nanni, Valentina Ambrosini, Daniela D'Ambrosio, Korinne Di Leo, Silvia Angelucci, Federico Zagni, Filippo Lodi, Mario Marengo, William A. Weiss, Andrea Pession, Roberto Tonelli, Stefano Fanti

Research output: Contribution to journalArticlepeer-review

Abstract

Purpose: TH-MYCN transgenic mice represent a valuable preclinical model of neuroblastoma. Current methods to study tumor progression in these mice are inaccurate or invasive, limiting the potential of this murine model. The aim of our study was to assess the potential of small animal positron emission tomography (SA-PET) to study neuroblastoma progression in TH-MYCN mice. Procedure: Serial SA-PET scans using the tracer 2-deoxy-2-[18F] fluoro-d-glucose (18F-FDG) have been performed in TH-MYCN mice. Image analysis of tumor progression has been compared with ex vivo evaluation of tumor volumes and histological features. Results: [18F]FDG-SA-PET allowed to detect early staged tumors in almost 100 % of TH-MYCN mice positive for disease. Image analysis of tumor evolution reflected the modifications of the tumor volume, histological features, and malignancy during disease progression. Image analysis of TH-MYCN mice undergoing chemotherapy treatment against neuroblastoma provided information on drug-induced alterations in tumor metabolic activity. Conclusions: These data show for the first time that [ 18F]FDG-SA-PET is a useful tool to study neuroblastoma presence and progression in TH-MYCN transgenic mice.

Original languageEnglish
Pages (from-to)194-202
Number of pages9
JournalMolecular Imaging and Biology
Volume15
Issue number2
DOIs
Publication statusPublished - 2013

Keywords

  • [F]FDG
  • Neuroblastoma
  • Small animal PET
  • TH-MYCN mice

ASJC Scopus subject areas

  • Cancer Research
  • Oncology
  • Radiology Nuclear Medicine and imaging

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