Molecular insights into the disease mechanisms of type II mixed cryoglobulinemia

Valli De Re, Marica Garziera

Research output: Chapter in Book/Report/Conference proceedingChapter


Several epidemiological and clinico-pathological observations suggest that the pathogenesis of type II MC (MC-II) is multifactorial and multistep. Strongly associated with MC-II is the presence of cryoprecipitates, thought to be involved in the maintenance and perpetuation of the disease. The biological characteristics of MC-II cryoglobulins are extremely relevant to the etiopathogenetic mechanisms linking hepatitis C virus antigen stimulation to autoimmunity and to lymphoproliferation. Currently, there are no data clearly demonstrating the component responsible for cryoprecipitation. However, several findings from studies of cryoimmunoglobulin glycosylation together with the characterization of monoclonal IgM rheumatoid factor activity/recognition may provide a better understanding of the pathologic process linking cryoprecipitation with hepatitis C virus infection.

Original languageEnglish
Title of host publicationHCV Infection and Cryoglobulinemia
PublisherSpringer-Verlag Italia s.r.l.
Number of pages5
ISBN (Print)9788847017054, 8847017041, 9788847017047
Publication statusPublished - Apr 1 2012

ASJC Scopus subject areas

  • Medicine(all)

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