Molecular investigation of coexistent chronic myeloid leukaemia and peripheral T-cell lymphoma-a case report

Research output: Contribution to journalArticlepeer-review

Abstract

Chronic myeloid leukemia (CML) is a myeloproliferative neoplasm underlain by the formation of BCR-ABL1-an aberrant tyrosine kinase-in the leukaemic blasts. Long-term survival rates in CML prior to the advent of tyrosine kinase inhibitors (TKIs) were dismal, albeit the incidence of secondary malignancies was higher than that of age-matched population. Current figures confirm the safety of TKIs with conflicting data concerning the increased risk of secondary tumours. We postulate that care has to be taken when distinguishing between coexisting, secondary-to-treatment and second in sequence, but independent tumourigenic events, in order to achieve an unbiased picture of the adverse effects of novel treatments. To illustrate this point, we present a case of a patient in which CML and peripheral T-cell lymphoma (PTCL) coexisted, although the clinical presentation of the latter followed the achievement of major molecular response of CML to TKIs.

Original languageEnglish
Article number14829
JournalScientific Reports
Volume5
DOIs
Publication statusPublished - Oct 6 2015

ASJC Scopus subject areas

  • General

Fingerprint

Dive into the research topics of 'Molecular investigation of coexistent chronic myeloid leukaemia and peripheral T-cell lymphoma-a case report'. Together they form a unique fingerprint.

Cite this