Abstract
Original language | English |
---|---|
Journal | Front. Immunol. |
Volume | 10 |
DOIs | |
Publication status | Published - 2020 |
Keywords
- autoimmunity
- epigenetic regulation
- Foxp3
- Foxp3 stability
- Treg cells
- histone
- microRNA
- transcription factor FOXP3
- forkhead transcription factor
- FOXP3 protein, human
- autoimmune disease
- cell fate
- cell function
- cell plasticity
- epigenetics
- gene expression
- gene locus
- human
- inflammation
- protein processing
- protein stability
- regulatory T lymphocyte
- Review
- transcription regulation
- animal
- biosynthesis
- cell differentiation
- gene expression regulation
- genetic epigenesis
- genetics
- immunology
- metabolism
- physiology
- T lymphocyte subpopulation
- Animals
- Autoimmunity
- Cell Differentiation
- Epigenesis, Genetic
- Forkhead Transcription Factors
- Gene Expression Regulation
- Humans
- T-Lymphocyte Subsets
- T-Lymphocytes, Regulatory
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Molecular Mechanisms Controlling Foxp3 Expression in Health and Autoimmunity: From Epigenetic to Post-translational Regulation : Frontiers in Immunology. / Colamatteo, A.; Carbone, F.; Bruzzaniti, S.; Galgani, M.; Fusco, C.; Maniscalco, G.T.; Di Rella, F.; de Candia, P.; De Rosa, V.
In: Front. Immunol., Vol. 10, 2020.Research output: Contribution to journal › Article › peer-review
}
TY - JOUR
T1 - Molecular Mechanisms Controlling Foxp3 Expression in Health and Autoimmunity: From Epigenetic to Post-translational Regulation
T2 - Frontiers in Immunology
AU - Colamatteo, A.
AU - Carbone, F.
AU - Bruzzaniti, S.
AU - Galgani, M.
AU - Fusco, C.
AU - Maniscalco, G.T.
AU - Di Rella, F.
AU - de Candia, P.
AU - De Rosa, V.
N1 - Cited By :5 Export Date: 5 March 2021 Correspondence Address: De Rosa, V.; Laboratorio di Immunologia, Italy; email: veronica.derosa@cnr.it Chemicals/CAS: histone, 9062-68-4; Forkhead Transcription Factors; FOXP3 protein, human Funding details: PP-1606-24687, PP-1804-30725 Funding details: National Multiple Sclerosis Society Funding details: Università degli Studi di Napoli Federico II, UNINA Funding details: Fondazione Italiana Sclerosi Multipla, FISM, 2016/R/10, 2018/R/4 Funding details: Compagnia di San Paolo Funding details: Juvenile Diabetes Research Foundation United States of America, JDRF, 1-SRA-2018-477-S-B, 2-SRA-2018-479-S-B Funding details: Juvenile Diabetes Research Foundation Australia Funding details: Ministero della Salute, GR-2016-02363725 Funding text 1: This paper was supported by grants from Fondazione Italiana Sclerosi Multipla (FISM no. 2018/R/4 to VD, and no. 2016/R/10 to PC), Ministero della Salute grant (no. GR-2016-02363725) to VD and FC, the Università degli Studi di Napoli Federico II (STAR Program Linea 1−2018 funded by UniNA and Compagnia di San Paolo) to VD, the Juvenile Diabetes Research Foundation (JDRF no. 2-SRA-2018-479-S-B to MG and no. 1-SRA-2018-477-S-B to PC), and the National Multiple Sclerosis Society (NMSS no. PP-1804-30725 to MG and PP-1606-24687 to PC). Part of images used in the figure preparation was from the Motifolio drawing toolkits (www.motifolio.com). 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PY - 2020
Y1 - 2020
N2 - The discovery of the transcription factor Forkhead box-p3 (Foxp3) has shed fundamental insights into the understanding of the molecular determinants leading to generation and maintenance of T regulatory (Treg) cells, a cell population with a key immunoregulatory role. Work over the past few years has shown that fine-tuned transcriptional and epigenetic events are required to ensure stable expression of Foxp3 in Treg cells. The equilibrium between phenotypic plasticity and stability of Treg cells is controlled at the molecular level by networks of transcription factors that bind regulatory sequences, such as enhancers and promoters, to regulate Foxp3 expression. Recent reports have suggested that specific modifications of DNA and histones are required for the establishment of the chromatin structure in conventional CD4+ T (Tconv) cells for their future differentiation into the Treg cell lineage. In this review, we discuss the molecular events that control Foxp3 gene expression and address the associated alterations observed in human diseases. Also, we explore how Foxp3 influences the gene expression programs in Treg cells and how unique properties of Treg cell subsets are defined by other transcription factors. © Copyright © 2020 Colamatteo, Carbone, Bruzzaniti, Galgani, Fusco, Maniscalco, Di Rella, de Candia and De Rosa.
AB - The discovery of the transcription factor Forkhead box-p3 (Foxp3) has shed fundamental insights into the understanding of the molecular determinants leading to generation and maintenance of T regulatory (Treg) cells, a cell population with a key immunoregulatory role. Work over the past few years has shown that fine-tuned transcriptional and epigenetic events are required to ensure stable expression of Foxp3 in Treg cells. The equilibrium between phenotypic plasticity and stability of Treg cells is controlled at the molecular level by networks of transcription factors that bind regulatory sequences, such as enhancers and promoters, to regulate Foxp3 expression. Recent reports have suggested that specific modifications of DNA and histones are required for the establishment of the chromatin structure in conventional CD4+ T (Tconv) cells for their future differentiation into the Treg cell lineage. In this review, we discuss the molecular events that control Foxp3 gene expression and address the associated alterations observed in human diseases. Also, we explore how Foxp3 influences the gene expression programs in Treg cells and how unique properties of Treg cell subsets are defined by other transcription factors. © Copyright © 2020 Colamatteo, Carbone, Bruzzaniti, Galgani, Fusco, Maniscalco, Di Rella, de Candia and De Rosa.
KW - autoimmunity
KW - epigenetic regulation
KW - Foxp3
KW - Foxp3 stability
KW - Treg cells
KW - histone
KW - microRNA
KW - transcription factor FOXP3
KW - forkhead transcription factor
KW - FOXP3 protein, human
KW - autoimmune disease
KW - cell fate
KW - cell function
KW - cell plasticity
KW - epigenetics
KW - gene expression
KW - gene locus
KW - human
KW - inflammation
KW - protein processing
KW - protein stability
KW - regulatory T lymphocyte
KW - Review
KW - transcription regulation
KW - animal
KW - biosynthesis
KW - cell differentiation
KW - gene expression regulation
KW - genetic epigenesis
KW - genetics
KW - immunology
KW - metabolism
KW - physiology
KW - T lymphocyte subpopulation
KW - Animals
KW - Autoimmunity
KW - Cell Differentiation
KW - Epigenesis, Genetic
KW - Forkhead Transcription Factors
KW - Gene Expression Regulation
KW - Humans
KW - T-Lymphocyte Subsets
KW - T-Lymphocytes, Regulatory
U2 - 10.3389/fimmu.2019.03136
DO - 10.3389/fimmu.2019.03136
M3 - Article
VL - 10
JO - Front. Immunol.
JF - Front. Immunol.
SN - 1664-3224
ER -