Molecular mechanisms controlling sensitivity to toxic metal ions in yeast

Paola Perego, Stephen B. Howell

Research output: Contribution to journalArticle

Abstract

Contamination of the environment has made toxic metal ions a major health issue. The use of yeasts as model systems for the identification of molecular mechanisms that control sensitivity to these agents is particularly attractive because of the ease of genetic manipulation and the availability of the complete Saccharomyces cerevisiae genomic sequence. This paper reviews information on those genes and mechanisms that have been identified in both the budding yeast S. cerevisiae and the fission yeast Schizosaccharomyces pombe as being capable of modulating sensitivity to important toxic metals. The factors that influence sensitivity to toxic metal ions include cellular thiols (glutathione, phytochelatins, labile sulfide, and metallothioneins) and the products of genes directly and indirectly involved in the transport or sequestration of the metal ion. A complete understanding of the molecular basis of sensitivity to toxic metal ions in lower organisms is expected to provide useful insights in the metal ion detoxification pathways and diseases related to these pathways in humans.

Original languageEnglish
Pages (from-to)312-318
Number of pages7
JournalToxicology and Applied Pharmacology
Volume147
Issue number2
DOIs
Publication statusPublished - Dec 1997

Fingerprint

Poisons
Yeast
Metal ions
Yeasts
Metals
Ions
Schizosaccharomyces
Phytochelatins
Genes
Saccharomyces cerevisiae
Detoxification
Metallothionein
Sulfides
Saccharomycetales
Sulfhydryl Compounds
Glutathione
Identification (control systems)
Contamination
Health
Availability

ASJC Scopus subject areas

  • Pharmacology
  • Toxicology

Cite this

Molecular mechanisms controlling sensitivity to toxic metal ions in yeast. / Perego, Paola; Howell, Stephen B.

In: Toxicology and Applied Pharmacology, Vol. 147, No. 2, 12.1997, p. 312-318.

Research output: Contribution to journalArticle

@article{ee6012fbd7f149e29f4058c5443df21c,
title = "Molecular mechanisms controlling sensitivity to toxic metal ions in yeast",
abstract = "Contamination of the environment has made toxic metal ions a major health issue. The use of yeasts as model systems for the identification of molecular mechanisms that control sensitivity to these agents is particularly attractive because of the ease of genetic manipulation and the availability of the complete Saccharomyces cerevisiae genomic sequence. This paper reviews information on those genes and mechanisms that have been identified in both the budding yeast S. cerevisiae and the fission yeast Schizosaccharomyces pombe as being capable of modulating sensitivity to important toxic metals. The factors that influence sensitivity to toxic metal ions include cellular thiols (glutathione, phytochelatins, labile sulfide, and metallothioneins) and the products of genes directly and indirectly involved in the transport or sequestration of the metal ion. A complete understanding of the molecular basis of sensitivity to toxic metal ions in lower organisms is expected to provide useful insights in the metal ion detoxification pathways and diseases related to these pathways in humans.",
author = "Paola Perego and Howell, {Stephen B.}",
year = "1997",
month = "12",
doi = "10.1006/taap.1997.8271",
language = "English",
volume = "147",
pages = "312--318",
journal = "Toxicology and Applied Pharmacology",
issn = "0041-008X",
publisher = "Academic Press Inc.",
number = "2",

}

TY - JOUR

T1 - Molecular mechanisms controlling sensitivity to toxic metal ions in yeast

AU - Perego, Paola

AU - Howell, Stephen B.

PY - 1997/12

Y1 - 1997/12

N2 - Contamination of the environment has made toxic metal ions a major health issue. The use of yeasts as model systems for the identification of molecular mechanisms that control sensitivity to these agents is particularly attractive because of the ease of genetic manipulation and the availability of the complete Saccharomyces cerevisiae genomic sequence. This paper reviews information on those genes and mechanisms that have been identified in both the budding yeast S. cerevisiae and the fission yeast Schizosaccharomyces pombe as being capable of modulating sensitivity to important toxic metals. The factors that influence sensitivity to toxic metal ions include cellular thiols (glutathione, phytochelatins, labile sulfide, and metallothioneins) and the products of genes directly and indirectly involved in the transport or sequestration of the metal ion. A complete understanding of the molecular basis of sensitivity to toxic metal ions in lower organisms is expected to provide useful insights in the metal ion detoxification pathways and diseases related to these pathways in humans.

AB - Contamination of the environment has made toxic metal ions a major health issue. The use of yeasts as model systems for the identification of molecular mechanisms that control sensitivity to these agents is particularly attractive because of the ease of genetic manipulation and the availability of the complete Saccharomyces cerevisiae genomic sequence. This paper reviews information on those genes and mechanisms that have been identified in both the budding yeast S. cerevisiae and the fission yeast Schizosaccharomyces pombe as being capable of modulating sensitivity to important toxic metals. The factors that influence sensitivity to toxic metal ions include cellular thiols (glutathione, phytochelatins, labile sulfide, and metallothioneins) and the products of genes directly and indirectly involved in the transport or sequestration of the metal ion. A complete understanding of the molecular basis of sensitivity to toxic metal ions in lower organisms is expected to provide useful insights in the metal ion detoxification pathways and diseases related to these pathways in humans.

UR - http://www.scopus.com/inward/record.url?scp=0031422659&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0031422659&partnerID=8YFLogxK

U2 - 10.1006/taap.1997.8271

DO - 10.1006/taap.1997.8271

M3 - Article

C2 - 9439726

AN - SCOPUS:0031422659

VL - 147

SP - 312

EP - 318

JO - Toxicology and Applied Pharmacology

JF - Toxicology and Applied Pharmacology

SN - 0041-008X

IS - 2

ER -