Abstract
Original language | English |
---|---|
Article number | 111210 |
Journal | Mech. Ageing Dev. |
Volume | 186 |
DOIs | |
Publication status | Published - 2020 |
Keywords
- Cognitive frailty
- Gut microbiota
- Inflammation
- Oxidative stress
- Oxygen-ozone therapy
- Trace elements
- cytokine
- hypoxia inducible factor 1alpha
- immunoglobulin enhancer binding protein
- transcription factor AP 1
- transcription factor NFAT
- transcription factor Nrf2
- aging
- apoptosis
- cognitive defect
- cognitive frailty
- disorders of mitochondrial functions
- DNA damage
- epigenetics
- frailty
- human
- immunoregulation
- inflammation
- intestine flora
- metabolic disorder
- nonhuman
- oxidative stress
- oxygen consumption
- oxygen therapy
- ozone therapy
- pathophysiology
- priority journal
- regeneration
- Review
- risk factor
- stem cell
- vasodilatation
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Molecular mechanisms in cognitive frailty: potential therapeutic targets for oxygen-ozone treatment : Mechanisms of Ageing and Development. / Scassellati, C.; Ciani, M.; Galoforo, A.C.; Zanardini, R.; Bonvicini, C.; Geroldi, C.
In: Mech. Ageing Dev., Vol. 186, 111210, 2020.Research output: Contribution to journal › Article › peer-review
}
TY - JOUR
T1 - Molecular mechanisms in cognitive frailty: potential therapeutic targets for oxygen-ozone treatment
T2 - Mechanisms of Ageing and Development
AU - Scassellati, C.
AU - Ciani, M.
AU - Galoforo, A.C.
AU - Zanardini, R.
AU - Bonvicini, C.
AU - Geroldi, C.
N1 - Cited By :1 Export Date: 22 February 2021 CODEN: MAGDA Correspondence Address: Bonvicini, C.; Molecular Markers Laboratory, Brescia Via Pilastroni 4, Italy; email: cbonvicini@fatebenefratelli.eu Chemicals/CAS: transcription factor NFAT, 292890-46-1 Funding details: RF-2016-02363298 Funding text 1: This research was supported by grants from the Italian Ministry of Health as Ricerca Corrente and as RF-2016-02363298 . References: Abdelhafiz, A.H., Sinclair, A.J., Cognitive frailty in older people with type 2 diabetes mellitus: the central role of hypoglycaemia and the need for prevention (2019) Curr. Diab. Rep., 19; Ahmed, S.M., Luo, L., Namani, A., Wang, X.J., Tang, X., Nrf2 signaling pathway: Pivotal roles in inflammation. Biochimica et biophysica acta (2017) Molecular basis of disease, 1863, pp. 585-597; Alpan, A.L., Toker, H., Ozer, H., Ozone therapy enhances osseous healing in rats with diabetes with calvarial defects: a morphometric and immunohistochemical study (2016) J. 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Thorac. Cardiovasc. Surg., 139. , 1286-94, 1294.e1-2
PY - 2020
Y1 - 2020
N2 - In the last decade, cognitive frailty has gained great attention from the scientific community. It is characterized by high inflammation and oxidant state, endocrine and metabolic alterations, mitochondria dysfunctions and slowdown in regenerative processes and immune system, with a complex and multifactorial aetiology. Although several treatments are available, challenges regarding the efficacy and the costs persist. Here, we proposed an alternative non-pharmacological, non-side-effect, low cost therapy based on anti-inflammation, antioxidant, regenerative and anti-pathogens properties of ozone, through the activation of several molecular mechanisms (Nrf2-ARE, NF-κB, NFAT, AP-1, HIFα). We highlighted how these specific processes could be implicated in cognitive frailty to identify putative therapeutic targets for its treatment. The oxigen-ozone (O2-O3) therapy has never been tested for cognitive frailty. This work provides thus wide scientific background to build a consistent rationale for testing for the first time this therapy, that could modulate the immune, inflammatory, oxidant, metabolic, endocrine, microbiota and regenerative processes impaired in cognitive frailty. Although insights are needed, the O2-O3 therapy could represent a faster, easier, inexpensive monodomain intervention working in absence of side effects for cognitive frailty. © 2020 The Authors
AB - In the last decade, cognitive frailty has gained great attention from the scientific community. It is characterized by high inflammation and oxidant state, endocrine and metabolic alterations, mitochondria dysfunctions and slowdown in regenerative processes and immune system, with a complex and multifactorial aetiology. Although several treatments are available, challenges regarding the efficacy and the costs persist. Here, we proposed an alternative non-pharmacological, non-side-effect, low cost therapy based on anti-inflammation, antioxidant, regenerative and anti-pathogens properties of ozone, through the activation of several molecular mechanisms (Nrf2-ARE, NF-κB, NFAT, AP-1, HIFα). We highlighted how these specific processes could be implicated in cognitive frailty to identify putative therapeutic targets for its treatment. The oxigen-ozone (O2-O3) therapy has never been tested for cognitive frailty. This work provides thus wide scientific background to build a consistent rationale for testing for the first time this therapy, that could modulate the immune, inflammatory, oxidant, metabolic, endocrine, microbiota and regenerative processes impaired in cognitive frailty. Although insights are needed, the O2-O3 therapy could represent a faster, easier, inexpensive monodomain intervention working in absence of side effects for cognitive frailty. © 2020 The Authors
KW - Cognitive frailty
KW - Gut microbiota
KW - Inflammation
KW - Oxidative stress
KW - Oxygen-ozone therapy
KW - Trace elements
KW - cytokine
KW - hypoxia inducible factor 1alpha
KW - immunoglobulin enhancer binding protein
KW - transcription factor AP 1
KW - transcription factor NFAT
KW - transcription factor Nrf2
KW - aging
KW - apoptosis
KW - cognitive defect
KW - cognitive frailty
KW - disorders of mitochondrial functions
KW - DNA damage
KW - epigenetics
KW - frailty
KW - human
KW - immunoregulation
KW - inflammation
KW - intestine flora
KW - metabolic disorder
KW - nonhuman
KW - oxidative stress
KW - oxygen consumption
KW - oxygen therapy
KW - ozone therapy
KW - pathophysiology
KW - priority journal
KW - regeneration
KW - Review
KW - risk factor
KW - stem cell
KW - vasodilatation
U2 - 10.1016/j.mad.2020.111210
DO - 10.1016/j.mad.2020.111210
M3 - Article
VL - 186
JO - Mech. Ageing Dev.
JF - Mech. Ageing Dev.
SN - 0047-6374
M1 - 111210
ER -