Molecular mechanisms of cardiomyocyte regeneration and therapeutic outlook

Antonia Germani, Giuliana Di Rocco, Federica Limana, Fabio Martelli, Maurizio C. Capogrossi

Research output: Contribution to journalArticle

13 Citations (Scopus)

Abstract

Differently from some lower vertebrates, which can completely regenerate their heart, in higher vertebrates cardiac injury generally leads to progressive failure. Induction of cycle re-entry in terminally differentiated cardiomyocytes and stem-cell transplantation are strategies to increase the regenerative potential of the heart. As experimental and clinical studies progress, demonstrating that adult stem-cell administration has a favorable impact on myocardial function, the identification of cardiac stem cells suggests that some endogenous repair mechanisms actually exist in the mammalian heart. However, a deeper understanding of the mechanism that drives cardiomyocyte proliferation and stem-cell-mediated cardiac repair is required to translate such strategies into effective therapies.

Original languageEnglish
Pages (from-to)125-133
Number of pages9
JournalTrends in Molecular Medicine
Volume13
Issue number3
DOIs
Publication statusPublished - Mar 2007

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Cardiac Myocytes
Regeneration
Vertebrates
Stem Cells
Adult Stem Cells
Stem Cell Transplantation
Therapeutics
Wounds and Injuries

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Molecular mechanisms of cardiomyocyte regeneration and therapeutic outlook. / Germani, Antonia; Di Rocco, Giuliana; Limana, Federica; Martelli, Fabio; Capogrossi, Maurizio C.

In: Trends in Molecular Medicine, Vol. 13, No. 3, 03.2007, p. 125-133.

Research output: Contribution to journalArticle

Germani, Antonia ; Di Rocco, Giuliana ; Limana, Federica ; Martelli, Fabio ; Capogrossi, Maurizio C. / Molecular mechanisms of cardiomyocyte regeneration and therapeutic outlook. In: Trends in Molecular Medicine. 2007 ; Vol. 13, No. 3. pp. 125-133.
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