Molecular mechanisms of cardiomyocyte regeneration and therapeutic outlook

Antonia Germani, Giuliana Di Rocco, Federica Limana, Fabio Martelli, Maurizio C. Capogrossi

Research output: Contribution to journalArticlepeer-review

Abstract

Differently from some lower vertebrates, which can completely regenerate their heart, in higher vertebrates cardiac injury generally leads to progressive failure. Induction of cycle re-entry in terminally differentiated cardiomyocytes and stem-cell transplantation are strategies to increase the regenerative potential of the heart. As experimental and clinical studies progress, demonstrating that adult stem-cell administration has a favorable impact on myocardial function, the identification of cardiac stem cells suggests that some endogenous repair mechanisms actually exist in the mammalian heart. However, a deeper understanding of the mechanism that drives cardiomyocyte proliferation and stem-cell-mediated cardiac repair is required to translate such strategies into effective therapies.

Original languageEnglish
Pages (from-to)125-133
Number of pages9
JournalTrends in Molecular Medicine
Volume13
Issue number3
DOIs
Publication statusPublished - Mar 2007

ASJC Scopus subject areas

  • Medicine(all)

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