Abstract
Differently from some lower vertebrates, which can completely regenerate their heart, in higher vertebrates cardiac injury generally leads to progressive failure. Induction of cycle re-entry in terminally differentiated cardiomyocytes and stem-cell transplantation are strategies to increase the regenerative potential of the heart. As experimental and clinical studies progress, demonstrating that adult stem-cell administration has a favorable impact on myocardial function, the identification of cardiac stem cells suggests that some endogenous repair mechanisms actually exist in the mammalian heart. However, a deeper understanding of the mechanism that drives cardiomyocyte proliferation and stem-cell-mediated cardiac repair is required to translate such strategies into effective therapies.
| Original language | English |
|---|---|
| Pages (from-to) | 125-133 |
| Number of pages | 9 |
| Journal | Trends in Molecular Medicine |
| Volume | 13 |
| Issue number | 3 |
| DOIs | |
| Publication status | Published - Mar 2007 |
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ASJC Scopus subject areas
- Medicine(all)
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Molecular mechanisms of cardiomyocyte regeneration and therapeutic outlook. / Germani, Antonia; Di Rocco, Giuliana; Limana, Federica; Martelli, Fabio; Capogrossi, Maurizio C.
In: Trends in Molecular Medicine, Vol. 13, No. 3, 03.2007, p. 125-133.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Molecular mechanisms of cardiomyocyte regeneration and therapeutic outlook
AU - Germani, Antonia
AU - Di Rocco, Giuliana
AU - Limana, Federica
AU - Martelli, Fabio
AU - Capogrossi, Maurizio C.
PY - 2007/3
Y1 - 2007/3
N2 - Differently from some lower vertebrates, which can completely regenerate their heart, in higher vertebrates cardiac injury generally leads to progressive failure. Induction of cycle re-entry in terminally differentiated cardiomyocytes and stem-cell transplantation are strategies to increase the regenerative potential of the heart. As experimental and clinical studies progress, demonstrating that adult stem-cell administration has a favorable impact on myocardial function, the identification of cardiac stem cells suggests that some endogenous repair mechanisms actually exist in the mammalian heart. However, a deeper understanding of the mechanism that drives cardiomyocyte proliferation and stem-cell-mediated cardiac repair is required to translate such strategies into effective therapies.
AB - Differently from some lower vertebrates, which can completely regenerate their heart, in higher vertebrates cardiac injury generally leads to progressive failure. Induction of cycle re-entry in terminally differentiated cardiomyocytes and stem-cell transplantation are strategies to increase the regenerative potential of the heart. As experimental and clinical studies progress, demonstrating that adult stem-cell administration has a favorable impact on myocardial function, the identification of cardiac stem cells suggests that some endogenous repair mechanisms actually exist in the mammalian heart. However, a deeper understanding of the mechanism that drives cardiomyocyte proliferation and stem-cell-mediated cardiac repair is required to translate such strategies into effective therapies.
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UR - http://www.scopus.com/inward/citedby.url?scp=33847409770&partnerID=8YFLogxK
U2 - 10.1016/j.molmed.2007.01.002
DO - 10.1016/j.molmed.2007.01.002
M3 - Article
C2 - 17257896
AN - SCOPUS:33847409770
VL - 13
SP - 125
EP - 133
JO - Trends in Molecular Medicine
JF - Trends in Molecular Medicine
SN - 1471-4914
IS - 3
ER -