TY - JOUR
T1 - Molecular mechanisms of cardiomyocyte regeneration and therapeutic outlook
AU - Germani, Antonia
AU - Di Rocco, Giuliana
AU - Limana, Federica
AU - Martelli, Fabio
AU - Capogrossi, Maurizio C.
PY - 2007/3
Y1 - 2007/3
N2 - Differently from some lower vertebrates, which can completely regenerate their heart, in higher vertebrates cardiac injury generally leads to progressive failure. Induction of cycle re-entry in terminally differentiated cardiomyocytes and stem-cell transplantation are strategies to increase the regenerative potential of the heart. As experimental and clinical studies progress, demonstrating that adult stem-cell administration has a favorable impact on myocardial function, the identification of cardiac stem cells suggests that some endogenous repair mechanisms actually exist in the mammalian heart. However, a deeper understanding of the mechanism that drives cardiomyocyte proliferation and stem-cell-mediated cardiac repair is required to translate such strategies into effective therapies.
AB - Differently from some lower vertebrates, which can completely regenerate their heart, in higher vertebrates cardiac injury generally leads to progressive failure. Induction of cycle re-entry in terminally differentiated cardiomyocytes and stem-cell transplantation are strategies to increase the regenerative potential of the heart. As experimental and clinical studies progress, demonstrating that adult stem-cell administration has a favorable impact on myocardial function, the identification of cardiac stem cells suggests that some endogenous repair mechanisms actually exist in the mammalian heart. However, a deeper understanding of the mechanism that drives cardiomyocyte proliferation and stem-cell-mediated cardiac repair is required to translate such strategies into effective therapies.
UR - http://www.scopus.com/inward/record.url?scp=33847409770&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=33847409770&partnerID=8YFLogxK
U2 - 10.1016/j.molmed.2007.01.002
DO - 10.1016/j.molmed.2007.01.002
M3 - Article
C2 - 17257896
AN - SCOPUS:33847409770
VL - 13
SP - 125
EP - 133
JO - Trends in Molecular Medicine
JF - Trends in Molecular Medicine
SN - 1471-4914
IS - 3
ER -