Molecular mechanisms of diabetes reversibility after bariatric surgery

G. Rosa, G. Mingrone, M. Manco, V. Euthine, D. Gniuli, R. Calvani, M. Calvani, A. M R Favuzzi, M. Castagneto, H. Vidal

Research output: Contribution to journalArticle

Abstract

Objective: Insulin resistance is a strong biological marker of both obesity and type 2 diabetes. Abnormal fat deposition within skeletal muscle has been identified as a mechanism of obesity-associated insulin resistance. Biliopancreatic diversion (BPD), inducing a massive lipid malabsorption, leads to a reversion of type 2 diabetes. To elucidate the mechanisms of diabetes reversibility, the expression of genes involved in glucose and free fatty acids (FFAs) metabolism was investigated in skeletal muscle biopsies from obese, type 2 diabetic subjects. Peripheral insulin sensitivity and insulin secretion was also measured. Subjects: Eight Caucasian obese diabetic patients (BMI 52.1±1.85 kg/m2) were studied before and 3 years after BPD. Measurements: The mRNA levels were estimated by quantitative real-time reverse transcription polymerase chain reaction (RT-PCR), insulin sensitivity by the euglycemic-hyperinsulinemic clamp and insulin secretion using a model describing the relationship between insulin secretion and glucose concentration. Results: Whole-body glucose uptake (M), normalized by fat-free mass, significantly increased in post-obese subjects (P

Original languageEnglish
Pages (from-to)1429-1436
Number of pages8
JournalInternational Journal of Obesity
Volume31
Issue number9
DOIs
Publication statusPublished - Sep 2007

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Keywords

  • Biliopancreatic diversion
  • Gene expression
  • Insulin resistance
  • Morbid obesity
  • Type 2 diabetes

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Public Health, Environmental and Occupational Health
  • Endocrinology
  • Food Science
  • Endocrinology, Diabetes and Metabolism

Cite this

Rosa, G., Mingrone, G., Manco, M., Euthine, V., Gniuli, D., Calvani, R., Calvani, M., Favuzzi, A. M. R., Castagneto, M., & Vidal, H. (2007). Molecular mechanisms of diabetes reversibility after bariatric surgery. International Journal of Obesity, 31(9), 1429-1436. https://doi.org/10.1038/sj.ijo.0803630