Molecular mechanisms of glutamate-induced neurodegeneration

Maurizio Memo, Marina Pizzi, Alessandra Valerio, Mariagrazia Grilli, Pierfranco Spano

Research output: Contribution to journalArticle

Abstract

One of the unanswered questions surrounding the causes of Alzheimer's disease is how the two neuropathological hallmarks of the disease, i.e. amyloid plaques and neurofibrillary tangles, arise. In fact, up to now, little is known of the molecular events which lead to the synthesis of these very insoluble proteins and initiate a cascade of interlocking pathologies characterized by nerve terminal aberrancies, reactive gliosis, abnormal neuronal growth, and neuronal death. We suggest that, after certain unknown conditions, a number of selective neurons may modify the pattern of expression of a number of gene products in such a way as to react to specific stimuli in an abnormal fashion, perhaps incompatible with survival. Although Alzheimer's disease is complex in its origin and development, we suggest that abnormal glutamate reactivity may be one cause of neuronal death. This review will focus on some of the mechanisms triggered by glutamate, interacting with specific glutamate receptors, in relationship to neurodegeneration. Particular emphasis will be devoted to studies of the regulation of βamyloid and tau protein expression.

Original languageEnglish
Pages (from-to)339-348
Number of pages10
JournalInternational Review of Psychiatry
Volume7
Issue number3-4
DOIs
Publication statusPublished - 1995

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Glutamic Acid
Alzheimer Disease
Amyloidogenic Proteins
tau Proteins
Neurofibrillary Tangles
Gliosis
Amyloid Plaques
Glutamate Receptors
Cause of Death
Pathology
Neurons
Growth
Genes
Proteins

ASJC Scopus subject areas

  • Psychiatry and Mental health

Cite this

Molecular mechanisms of glutamate-induced neurodegeneration. / Memo, Maurizio; Pizzi, Marina; Valerio, Alessandra; Grilli, Mariagrazia; Spano, Pierfranco.

In: International Review of Psychiatry, Vol. 7, No. 3-4, 1995, p. 339-348.

Research output: Contribution to journalArticle

Memo, M, Pizzi, M, Valerio, A, Grilli, M & Spano, P 1995, 'Molecular mechanisms of glutamate-induced neurodegeneration', International Review of Psychiatry, vol. 7, no. 3-4, pp. 339-348. https://doi.org/10.3109/09540269509022986
Memo, Maurizio ; Pizzi, Marina ; Valerio, Alessandra ; Grilli, Mariagrazia ; Spano, Pierfranco. / Molecular mechanisms of glutamate-induced neurodegeneration. In: International Review of Psychiatry. 1995 ; Vol. 7, No. 3-4. pp. 339-348.
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