Molecular mechanisms of RET-induced Hirschsprung pathogenesis

Francesca Lantieri, Paola Griseri, Isabella Ceccherini

Research output: Contribution to journalArticle

33 Citations (Scopus)

Abstract

The RET proto-oncogene is the major gene involved in the pathogenesis of Hirschsprung (HSCR), a complex genetic disease characterized by lack of ganglia along variable lengths of the gut. Here we present a survey of the different molecular mechanisms through which RET mutations lead to the disease development. Among these, loss of function, gain of function, apoptosis, aberrant splicing and decreased gene expression are exemplified and considered with respect to their pathogenetic impact. In particular, RET transcription regulation represents a new insight into the outline of HSCR susceptibility, and having reached important progress in the last few years, deserves to be reviewed. Notably, gene expression impairment seems to be at the basis of the association of HSCR disease with several RET polymorphisms, allowing us to define a predisposing haplotype spanning from the promoter to exon 2. Putative functional variants, in the promoter and in intron 1, and proposed as low penetrant predisposing alleles, are presented and discussed. Finally, based on the RET mutation effects thus summarized, we attempt to derive conclusions which may be useful for HSCR risk prediction and genetic counselling.

Original languageEnglish
Pages (from-to)11-19
Number of pages9
JournalAnnals of Medicine
Volume38
Issue number1
DOIs
Publication statusPublished - Mar 2006

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Gene Expression
Hirschsprung Disease
Mutation
Inborn Genetic Diseases
Proto-Oncogenes
Genetic Counseling
Ganglia
Introns
Haplotypes
Exons
Alleles
Apoptosis
Genes
Surveys and Questionnaires

Keywords

  • Apoptosis
  • Complex inheritance
  • Disease predisposition
  • Genetic counselling
  • Hirschsprung disease
  • Loss-of-function
  • Molecular pathogenesis
  • RET proto-oncogene
  • RNA splicing
  • Transcription regulation

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Molecular mechanisms of RET-induced Hirschsprung pathogenesis. / Lantieri, Francesca; Griseri, Paola; Ceccherini, Isabella.

In: Annals of Medicine, Vol. 38, No. 1, 03.2006, p. 11-19.

Research output: Contribution to journalArticle

Lantieri, Francesca ; Griseri, Paola ; Ceccherini, Isabella. / Molecular mechanisms of RET-induced Hirschsprung pathogenesis. In: Annals of Medicine. 2006 ; Vol. 38, No. 1. pp. 11-19.
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