Molecular mechanisms that desensitize metabotropic glutamate receptor signaling: An overview

Luisa Iacovelli, Ferdinando Nicoletti, Antonio De Blasi

Research output: Contribution to journalArticle

Abstract

The purpose of the present article is to review our actual knowledge on the desensitization of metabotropic glutamate receptors based on the literature available so far, with the attempt to emphasize all converging data and to give a possible explanation to those evidences that still remain controversial. 1. We review our knowledge on the regulation of mGlu receptors based on the available literature 2. We report converging data and we comment on issues that still remain controversial. This article is part of a Special Issue entitled 'Metabotropic Glutamate Receptors'.

Original languageEnglish
Pages (from-to)24-30
Number of pages7
JournalNeuropharmacology
Volume66
DOIs
Publication statusPublished - Mar 2013

Keywords

  • Arrestins
  • GRKs
  • Metabotropic glutamate receptors
  • Receptor desensitization

ASJC Scopus subject areas

  • Cellular and Molecular Neuroscience
  • Pharmacology

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