Molecular mimicry by herpes simplex virus-type 1: Autoimmune disease after viral infection

Zi Shan Zhao, Francesca Granucci, Lily Yeh, Priscilla A. Schaffer, Harvey Cantor

Research output: Contribution to journalArticlepeer-review

Abstract

Viral infection is sometimes associated with the initiation or exacerbation of autoimmune disease, although the underlying mechanisms remain unclear. One proposed mechanism is that viral determinants that mimic host antigens trigger self-reactive T cell clones to destroy host tissue. An epitope expressed by a coat protein of herpes simplex virus-type 1 (HSV-1) KOS strain has now been shown to be recognized by autoreactive T cells that target corneal antigens in a murine model of autoimmune herpes stromal keratitis. Mutant HSV-1 viruses that lacked this epitope did not induce autoimmune disease. Thus, expression of molecular mimics can influence the development of autoimmune disease after viral infection.

Original languageEnglish
Pages (from-to)1344-1347
Number of pages4
JournalScience
Volume279
Issue number5355
DOIs
Publication statusPublished - Feb 27 1998

ASJC Scopus subject areas

  • General

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