Valutazione molecolare nella leucemia mieloide cronica

Translated title of the contribution: Molecular monitoring in chronic myeloid leukemia (CML)

Barbara Izzo, Raffaella Accetta, Simona Caruso, Biagio De Angelis, Ciro Del Prete, Santa Errichiello, Alessandra Galdiero, Giada Muccioli Casadei, Filomena Musella, Concetta Quintarelli, Roberta Visconti, Fabrizio Pane

Research output: Contribution to journalArticlepeer-review

Abstract

The pathognomonic genetic alteration in CML is the formation of the BCR-ABL fusion gene, which produces a constitutively active tyrosine kinase that drives leukemic transformation. Targeted tyrosine kinase inhibitor treatment is the cornerstone of modern therapy for this hematologic malignancy. Analysis of BCR-ABL [through reverse transcriptase-quantitative polymerase chain reaction (RT-QPCR)] is the gold standard approach for quantitatively assessing minimal residual disease and monitoring the efficacy of tyrosine kinase inhibitor therapy in CML patients. The continuous therapeutic improvement has led to increasingly ambitious treatment endpoints, which, in turn, require more and more refined measurement and definition of molecular response levels. For these reasons standardization efforts of monitoring by RT-QPCR are now focused on ensuring reliable and harmonized expression of quantitative results.

Translated title of the contributionMolecular monitoring in chronic myeloid leukemia (CML)
Original languageItalian
Pages (from-to)94-99
Number of pages6
JournalBiochimica Clinica
Volume39
Issue number2
Publication statusPublished - 2015

ASJC Scopus subject areas

  • Clinical Biochemistry
  • Biochemistry, medical
  • Medical Laboratory Technology

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