Abstract
Over the past few years, considerable technical effort has been directed to developing molecular methods that would allow an effective approach to the diagnosis of human immunodeficiency virus type 1 (HIV-1) infection and its monitoring. Indeed, quantitative molecular techniques have opened the way for a new type of direct study of untreated and treated HIV-1 infected subjects. The understanding of the immunopathogenesis of HIV-1 infection has increased significantly with the introduction of advanced virological and molecular methods for accurate quantitative analysis of HIV-1 activity; powerful methodologies answer (directly and in real time) most questions generated by pathogenic research and by the novel anti-viral strategies introduced in clinical practice. The data from pilot diagnostic applications of quantitative techniques have clarified important features of the natural history of HIV-1 infection. Moreover, an increasing amount of data indicate the need for second-level laboratory facilities for the clinical management of infected patients; virological aspects and some genetic features of the hosts concerning HIV-1 co-receptors (all the co-receptors so far identified are members of, or related to, the transmembrane, chemokine-receptor family) need to be elucidated for the complete diagnostic evaluation of HIV-1 infected subjects.
| Original language | English |
|---|---|
| Pages (from-to) | 64-68 |
| Number of pages | 5 |
| Journal | Journal of Biological Regulators and Homeostatic Agents |
| Volume | 11 |
| Issue number | 1-2 |
| Publication status | Published - Jan 1997 |
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Keywords
- Co-receptors
- HIV-1
- Receptors
- Transcripts
- Viral dynamics
- Viral load
ASJC Scopus subject areas
- Immunology
- Endocrinology, Diabetes and Metabolism
- Endocrinology
- Physiology (medical)
- Medicine (miscellaneous)
- Physiology
- Agricultural and Biological Sciences(all)
Cite this
Molecular monitoring of human immunodeficiency virus type 1 infection. / Clementi, M.; Bagnarelli, P.; Menzo, S.; Cardelli, M.; Mazzola, F.; Sampaolesi, R.
In: Journal of Biological Regulators and Homeostatic Agents, Vol. 11, No. 1-2, 01.1997, p. 64-68.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Molecular monitoring of human immunodeficiency virus type 1 infection
AU - Clementi, M.
AU - Bagnarelli, P.
AU - Menzo, S.
AU - Cardelli, M.
AU - Mazzola, F.
AU - Sampaolesi, R.
PY - 1997/1
Y1 - 1997/1
N2 - Over the past few years, considerable technical effort has been directed to developing molecular methods that would allow an effective approach to the diagnosis of human immunodeficiency virus type 1 (HIV-1) infection and its monitoring. Indeed, quantitative molecular techniques have opened the way for a new type of direct study of untreated and treated HIV-1 infected subjects. The understanding of the immunopathogenesis of HIV-1 infection has increased significantly with the introduction of advanced virological and molecular methods for accurate quantitative analysis of HIV-1 activity; powerful methodologies answer (directly and in real time) most questions generated by pathogenic research and by the novel anti-viral strategies introduced in clinical practice. The data from pilot diagnostic applications of quantitative techniques have clarified important features of the natural history of HIV-1 infection. Moreover, an increasing amount of data indicate the need for second-level laboratory facilities for the clinical management of infected patients; virological aspects and some genetic features of the hosts concerning HIV-1 co-receptors (all the co-receptors so far identified are members of, or related to, the transmembrane, chemokine-receptor family) need to be elucidated for the complete diagnostic evaluation of HIV-1 infected subjects.
AB - Over the past few years, considerable technical effort has been directed to developing molecular methods that would allow an effective approach to the diagnosis of human immunodeficiency virus type 1 (HIV-1) infection and its monitoring. Indeed, quantitative molecular techniques have opened the way for a new type of direct study of untreated and treated HIV-1 infected subjects. The understanding of the immunopathogenesis of HIV-1 infection has increased significantly with the introduction of advanced virological and molecular methods for accurate quantitative analysis of HIV-1 activity; powerful methodologies answer (directly and in real time) most questions generated by pathogenic research and by the novel anti-viral strategies introduced in clinical practice. The data from pilot diagnostic applications of quantitative techniques have clarified important features of the natural history of HIV-1 infection. Moreover, an increasing amount of data indicate the need for second-level laboratory facilities for the clinical management of infected patients; virological aspects and some genetic features of the hosts concerning HIV-1 co-receptors (all the co-receptors so far identified are members of, or related to, the transmembrane, chemokine-receptor family) need to be elucidated for the complete diagnostic evaluation of HIV-1 infected subjects.
KW - Co-receptors
KW - HIV-1
KW - Receptors
KW - Transcripts
KW - Viral dynamics
KW - Viral load
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UR - http://www.scopus.com/inward/citedby.url?scp=0030864240&partnerID=8YFLogxK
M3 - Article
C2 - 9418166
AN - SCOPUS:0030864240
VL - 11
SP - 64
EP - 68
JO - Journal of Biological Regulators and Homeostatic Agents
JF - Journal of Biological Regulators and Homeostatic Agents
SN - 0393-974X
IS - 1-2
ER -