Molecular monitoring of human immunodeficiency virus type 1 infection

M. Clementi, P. Bagnarelli, S. Menzo, M. Cardelli, F. Mazzola, R. Sampaolesi

Research output: Contribution to journalArticlepeer-review


Over the past few years, considerable technical effort has been directed to developing molecular methods that would allow an effective approach to the diagnosis of human immunodeficiency virus type 1 (HIV-1) infection and its monitoring. Indeed, quantitative molecular techniques have opened the way for a new type of direct study of untreated and treated HIV-1 infected subjects. The understanding of the immunopathogenesis of HIV-1 infection has increased significantly with the introduction of advanced virological and molecular methods for accurate quantitative analysis of HIV-1 activity; powerful methodologies answer (directly and in real time) most questions generated by pathogenic research and by the novel anti-viral strategies introduced in clinical practice. The data from pilot diagnostic applications of quantitative techniques have clarified important features of the natural history of HIV-1 infection. Moreover, an increasing amount of data indicate the need for second-level laboratory facilities for the clinical management of infected patients; virological aspects and some genetic features of the hosts concerning HIV-1 co-receptors (all the co-receptors so far identified are members of, or related to, the transmembrane, chemokine-receptor family) need to be elucidated for the complete diagnostic evaluation of HIV-1 infected subjects.

Original languageEnglish
Pages (from-to)64-68
Number of pages5
JournalJournal of Biological Regulators and Homeostatic Agents
Issue number1-2
Publication statusPublished - Jan 1997


  • Co-receptors
  • HIV-1
  • Receptors
  • Transcripts
  • Viral dynamics
  • Viral load

ASJC Scopus subject areas

  • Immunology
  • Endocrinology, Diabetes and Metabolism
  • Endocrinology
  • Physiology (medical)
  • Medicine (miscellaneous)
  • Physiology
  • Agricultural and Biological Sciences(all)


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