Molecular monitoring of human immunodeficiency virus type 1 infection

M. Clementi, P. Bagnarelli, S. Menzo, M. Cardelli, F. Mazzola, R. Sampaolesi

Research output: Contribution to journalArticle

Abstract

Over the past few years, considerable technical effort has been directed to developing molecular methods that would allow an effective approach to the diagnosis of human immunodeficiency virus type 1 (HIV-1) infection and its monitoring. Indeed, quantitative molecular techniques have opened the way for a new type of direct study of untreated and treated HIV-1 infected subjects. The understanding of the immunopathogenesis of HIV-1 infection has increased significantly with the introduction of advanced virological and molecular methods for accurate quantitative analysis of HIV-1 activity; powerful methodologies answer (directly and in real time) most questions generated by pathogenic research and by the novel anti-viral strategies introduced in clinical practice. The data from pilot diagnostic applications of quantitative techniques have clarified important features of the natural history of HIV-1 infection. Moreover, an increasing amount of data indicate the need for second-level laboratory facilities for the clinical management of infected patients; virological aspects and some genetic features of the hosts concerning HIV-1 co-receptors (all the co-receptors so far identified are members of, or related to, the transmembrane, chemokine-receptor family) need to be elucidated for the complete diagnostic evaluation of HIV-1 infected subjects.

Original languageEnglish
Pages (from-to)64-68
Number of pages5
JournalJournal of Biological Regulators and Homeostatic Agents
Volume11
Issue number1-2
Publication statusPublished - Jan 1997

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Keywords

  • Co-receptors
  • HIV-1
  • Receptors
  • Transcripts
  • Viral dynamics
  • Viral load

ASJC Scopus subject areas

  • Immunology
  • Endocrinology, Diabetes and Metabolism
  • Endocrinology
  • Physiology (medical)
  • Medicine (miscellaneous)
  • Physiology
  • Agricultural and Biological Sciences(all)

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