Molecular networks in melanoma invasion and metastasis

Ewa Aladowicz, Leda Ferro, Giulio Cesare Vitali, Elisabetta Venditti, Lorenzo Fornasari, Luisa Lanfrancone

Research output: Contribution to journalArticlepeer-review

Abstract

Metastatic melanoma accounts for approximately 80% of skin cancer-related deaths. Up to now there has been no effective treatment for stage IV melanoma patients due to the complexity and dissemination potential of this disease. Melanomas are heterogeneous tumors in which conventional therapies fail to improve overall survival. Targeted therapies are being developed, but the final outcome can be hampered by the incomplete knowledge of the process of melanoma progression. Even if the intracellular pathways are similar, the interaction of the cells with the surrounding environment should be taken into consideration. This article seeks to highlight some of the advances in the understanding of the molecular mechanisms underlying melanoma dissemination.

Original languageEnglish
Pages (from-to)713-726
Number of pages14
JournalFuture Oncology
Volume9
Issue number5
DOIs
Publication statusPublished - May 2013

Keywords

  • adhesion
  • melanoma
  • metastasis
  • migration
  • phenotype switching
  • RaLP/ShcD

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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