Molecular packing parameters of bipolar lipids

F. Cavagnetto, A. Relini, Z. Mirghani, A. Gliozzi, D. Bertoia, A. Gambacorta

Research output: Contribution to journalArticle

26 Citations (Scopus)

Abstract

The bipolar lipid fractions extracted from the thermophilic archaeobacterium Sulfolobus solfataricus have different chemical structures and geometrical shapes. The conditions which lead to the formation of vesicles were investigated in order to study the self-assembly of these molecules. Such conditions are fulfilled when an appropriate mixture of two different molecular species (both bipolar or bipolar and monopolar) is used. According to the theory introduced by Israelachvili and co-workers, lipid self-assembly results from the balance of interaction free energy, entropy and molecular geometry. We have shown that this theory can be extended to bipolar lipids, in spite of their more complex nature, and the experimental results obtained combining 1H-NMR, light scattering and entrapped volume techniques closely match theoretical expectations. To carry out calculations, it was necessary to introduce hypotheses about the disposition of bipolar molecules in the vesicle membrane. These hypotheses have been tested indirectly by measuring the transport properties mediated by carriers or channels, whose transport mechanism can be considered to be a probe of the membrane structure.

Original languageEnglish
Pages (from-to)273-281
Number of pages9
JournalBBA - Biomembranes
Volume1106
Issue number2
DOIs
Publication statusPublished - May 21 1992

Fingerprint

Lipids
Self assembly
Sulfolobus solfataricus
Membrane structures
Molecules
Membranes
Archaea
Entropy
Light scattering
Transport properties
Free energy
Nuclear magnetic resonance
Light
Geometry
Proton Magnetic Resonance Spectroscopy

Keywords

  • Bipolar lipid
  • Ionic transport
  • Molecular packing parameter
  • Monopolar-bipolar lipid vesicle
  • Self assembly

ASJC Scopus subject areas

  • Biochemistry
  • Biophysics
  • Cell Biology

Cite this

Cavagnetto, F., Relini, A., Mirghani, Z., Gliozzi, A., Bertoia, D., & Gambacorta, A. (1992). Molecular packing parameters of bipolar lipids. BBA - Biomembranes, 1106(2), 273-281. https://doi.org/10.1016/0005-2736(92)90006-8

Molecular packing parameters of bipolar lipids. / Cavagnetto, F.; Relini, A.; Mirghani, Z.; Gliozzi, A.; Bertoia, D.; Gambacorta, A.

In: BBA - Biomembranes, Vol. 1106, No. 2, 21.05.1992, p. 273-281.

Research output: Contribution to journalArticle

Cavagnetto, F, Relini, A, Mirghani, Z, Gliozzi, A, Bertoia, D & Gambacorta, A 1992, 'Molecular packing parameters of bipolar lipids', BBA - Biomembranes, vol. 1106, no. 2, pp. 273-281. https://doi.org/10.1016/0005-2736(92)90006-8
Cavagnetto F, Relini A, Mirghani Z, Gliozzi A, Bertoia D, Gambacorta A. Molecular packing parameters of bipolar lipids. BBA - Biomembranes. 1992 May 21;1106(2):273-281. https://doi.org/10.1016/0005-2736(92)90006-8
Cavagnetto, F. ; Relini, A. ; Mirghani, Z. ; Gliozzi, A. ; Bertoia, D. ; Gambacorta, A. / Molecular packing parameters of bipolar lipids. In: BBA - Biomembranes. 1992 ; Vol. 1106, No. 2. pp. 273-281.
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