Molecular pathology of endometrial carcinoma and its histopathological correlations: Beyond a dualistic vision?

Valerio Gaetano Vellone, Leonardo Peñuela, Riccardo Carbone, Chiara Maria Biatta, Bruno Spina, Fabio Barra, Simone Ferrero

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

Endometrial cancer (EC) accounts for about 4% of all female cancers and affects mainly postmenopausal women, representing a constantly growing disease especially in Western countries. Traditionally considered an indolent disease treated by surgery, it shows heterogeneous histological types, often presenting in advanced stages with greater biological aggressiveness. The dualistic classification proposed by Bokhman more than thirty years ago and confirmed by pivotal studies by Kurman et al. appears inadequate today, especially in light of numerous molecular studies. New perspectives on the pathogenesis and progression of EC appear to be have been supplied by recent genomic studies. Recently, TCGA (Cancer Genome Atlas Research Network) has divided ECs into 4 genomic classes: ultra-mutated POLE, microsatellite instability, low copy number, and serous “like” with a high number of copies. This classification seems to open up new opportunities in individualized therapeutic strategies. In this chapter, an extensive review of the main molecular markers involved in the pathogenesis and progression of EC is presented, including steroid hormone receptors, PTEN, PIK3CA, beta-catenin, Ecadherin, BCL-2, Cyclin D1, K- RAS, p53, p16, HER2/neu, Ki67, IMP3, ARID1A, C-myc, angiogenic factors, FGFR2, HGF, C-MET and MSI. Particular attention is given to the correlation between the different histological types and their possible implications for prognosis and individualized therapy.

Original languageEnglish
Title of host publicationEndometrial Cancer
Subtitle of host publicationRisk Factors, Management and Prognosis
PublisherNova Science Publishers, Inc.
Pages25-68
Number of pages44
ISBN (Electronic)9781536138887
ISBN (Print)9781536138870
Publication statusPublished - Jan 1 2018

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Keywords

  • Endometrial cancer
  • Molecular pathology

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Vellone, V. G., Peñuela, L., Carbone, R., Biatta, C. M., Spina, B., Barra, F., & Ferrero, S. (2018). Molecular pathology of endometrial carcinoma and its histopathological correlations: Beyond a dualistic vision? In Endometrial Cancer: Risk Factors, Management and Prognosis (pp. 25-68). Nova Science Publishers, Inc..