Abstract
Since the first description of intraductal papillary mucinous neoplasms (IPMNs) of the pancreas in the eighties, their identification has dramatically increased in the last decades, hand to hand with the improvements in diagnostic imaging and sampling techniques for the study of pancreatic diseases. However, the heterogeneity of IPMNs and their malignant potential make difficult the management of these lesions. The objective of this review is to identify the molecular characteristics of IPMNs in order to recognize potential markers for the discrimination of more aggressive IPMNs requiring surgical resection from benign IPMNs that could be observed. We briefly summarize recent research findings on the genetics and epigenetics of intraductal papillary mucinous neoplasms, identifying some genes, molecular mechanisms and cellular signaling pathways correlated to the pathogenesis of IPMNs and their progression to malignancy. The knowledge of molecular biology of IPMNs has impressively developed over the last few years. A great amount of genes functioning as oncogenes or tumor suppressor genes have been identified, in pancreatic juice or in blood or in the samples from the pancreatic resections, but further researches are required to use these informations for clinical intent, in order to better define the natural history of these diseases and to improve their management.
| Original language | English |
|---|---|
| Pages (from-to) | 10008-10023 |
| Number of pages | 16 |
| Journal | World Journal of Gastroenterology |
| Issue number | 29 |
| DOIs | |
| Publication status | Published - Aug 7 2014 |
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Keywords
- Dysplasia
- Intraductal papillary mucinous neoplasm
- Malignant transformation
- Molecular pathology
- Oncogene
- Pancreas
- Pancreatic cancer
- Tumor suppressor gene
ASJC Scopus subject areas
- Gastroenterology
- Medicine(all)
Cite this
Molecular pathology of intraductal papillary mucinous neoplasms of the pancreas. / Paini, Marina; Crippa, Stefano; Partelli, Stefano; Scopelliti, Filippo; Tamburrino, Domenico; Baldoni, Andrea; Falconi, Massimo.
In: World Journal of Gastroenterology, No. 29, 07.08.2014, p. 10008-10023.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Molecular pathology of intraductal papillary mucinous neoplasms of the pancreas
AU - Paini, Marina
AU - Crippa, Stefano
AU - Partelli, Stefano
AU - Scopelliti, Filippo
AU - Tamburrino, Domenico
AU - Baldoni, Andrea
AU - Falconi, Massimo
PY - 2014/8/7
Y1 - 2014/8/7
N2 - Since the first description of intraductal papillary mucinous neoplasms (IPMNs) of the pancreas in the eighties, their identification has dramatically increased in the last decades, hand to hand with the improvements in diagnostic imaging and sampling techniques for the study of pancreatic diseases. However, the heterogeneity of IPMNs and their malignant potential make difficult the management of these lesions. The objective of this review is to identify the molecular characteristics of IPMNs in order to recognize potential markers for the discrimination of more aggressive IPMNs requiring surgical resection from benign IPMNs that could be observed. We briefly summarize recent research findings on the genetics and epigenetics of intraductal papillary mucinous neoplasms, identifying some genes, molecular mechanisms and cellular signaling pathways correlated to the pathogenesis of IPMNs and their progression to malignancy. The knowledge of molecular biology of IPMNs has impressively developed over the last few years. A great amount of genes functioning as oncogenes or tumor suppressor genes have been identified, in pancreatic juice or in blood or in the samples from the pancreatic resections, but further researches are required to use these informations for clinical intent, in order to better define the natural history of these diseases and to improve their management.
AB - Since the first description of intraductal papillary mucinous neoplasms (IPMNs) of the pancreas in the eighties, their identification has dramatically increased in the last decades, hand to hand with the improvements in diagnostic imaging and sampling techniques for the study of pancreatic diseases. However, the heterogeneity of IPMNs and their malignant potential make difficult the management of these lesions. The objective of this review is to identify the molecular characteristics of IPMNs in order to recognize potential markers for the discrimination of more aggressive IPMNs requiring surgical resection from benign IPMNs that could be observed. We briefly summarize recent research findings on the genetics and epigenetics of intraductal papillary mucinous neoplasms, identifying some genes, molecular mechanisms and cellular signaling pathways correlated to the pathogenesis of IPMNs and their progression to malignancy. The knowledge of molecular biology of IPMNs has impressively developed over the last few years. A great amount of genes functioning as oncogenes or tumor suppressor genes have been identified, in pancreatic juice or in blood or in the samples from the pancreatic resections, but further researches are required to use these informations for clinical intent, in order to better define the natural history of these diseases and to improve their management.
KW - Dysplasia
KW - Intraductal papillary mucinous neoplasm
KW - Malignant transformation
KW - Molecular pathology
KW - Oncogene
KW - Pancreas
KW - Pancreatic cancer
KW - Tumor suppressor gene
UR - http://www.scopus.com/inward/record.url?scp=84905860660&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84905860660&partnerID=8YFLogxK
U2 - 10.3748/wjg.v20.i29.10008
DO - 10.3748/wjg.v20.i29.10008
M3 - Article
C2 - 25110429
AN - SCOPUS:84905860660
SP - 10008
EP - 10023
JO - World Journal of Gastroenterology
JF - World Journal of Gastroenterology
SN - 1007-9327
IS - 29
ER -