Molecular pathways for cancer angioprevention

Research output: Contribution to journalArticlepeer-review

Abstract

By analogy to the success of cardiovascular medicine in reducing mortality through preventive measures, cancer chemoprevention has the potential to significantly reduce incidence and mortality due to tumors. Angiogenesis is an event inhibited by most of the promising cancer chemoprevention compounds, a concept we termed "angioprevention." Here, we review the signaling pathways that are targeted by diverse angioprevention compounds in endothelial cells. We highlight diverse mechanisms of action, implying that combination angioprevention approaches could further improve efficacy and be transferred to clinical practice.

Original languageEnglish
Pages (from-to)4320-4325
Number of pages6
JournalClinical Cancer Research
Volume13
Issue number15
DOIs
Publication statusPublished - Aug 1 2007

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

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