Molecular portrait of breast cancer in China reveals comprehensive transcriptomic likeness to Caucasian breast cancer and low prevalence of luminal A subtype

Xiaoyan Huang, Matteo Dugo, Maurizio Callari, Marco Sandri, Loris De Cecco, Barbara Valeri, Maria Luisa Carcangiu, Jingyan Xue, Rui Bi, Silvia Veneroni, Maria Grazia Daidone, Sylvie Ménard, Elda Tagliabue, Zhimin Shao, Jiong Wu, Rosaria Orlandi

Research output: Contribution to journalArticle

17 Citations (Scopus)

Abstract

The recent dramatic increase in breast cancer incidence across China with progressive urbanization and economic development has signaled the urgent need for molecular and clinical detailing of breast cancer in the Chinese population. Our analyses of a unique transethnic collection of breast cancer frozen specimens from Shanghai Fudan Cancer Center (Chinese Han) profiled simultaneously with an analogous Caucasian Italian series revealed consistent transcriptomic data lacking in batch effects. The prevalence of Luminal A subtype was significantly lower in Chinese series, impacting the overall prevalence of estrogen receptor (ER)-positive disease in a large cohort of Chinese/Caucasian patients. Unsupervised and supervised comparison of gene and microRNA (miRNA) profiles of Chinese and Caucasian samples revealed extensive similarity in the comprehensive taxonomy of transcriptional elements regulating breast cancer biology. Partition of gene expression data using gene lists relevant to breast cancer as "intrinsic" and "extracellular matrix" genes identified Chinese and Caucasian subgroups with equivalent global gene and miRNA profiles. These findings indicate that in the Chinese and Caucasian groups, breast neoplasia and the surrounding stromal characteristics undergo the same differentiation and molecular processes. Transcriptional similarity across transethnic cohorts may simplify translational medicine approaches and clinical management of breast cancer patients worldwide. Our analyses of a unique transethnic collection of breast cancer frozen specimens from Shanghai Fudan Cancer Center (Chinese Han) profiled simultaneously with an analogous Caucasian Italian series revealed extensive similarity in the comprehensive taxonomy of transcriptional elements regulating breast cancer biology in Chinese and Caucasian groups. Transcriptional similarity across transethnic cohorts may simplify translational medicine approaches and clinical management of breast cancer patients worldwide.

Original languageEnglish
Pages (from-to)1016-1030
Number of pages15
JournalCancer Medicine
Volume4
Issue number7
DOIs
Publication statusPublished - Jul 1 2015

Fingerprint

China
Breast Neoplasms
Translational Medical Research
MicroRNAs
Genes
Neoplasms
Urbanization
Economic Development
Estrogen Receptors
Extracellular Matrix
Breast
Gene Expression
Incidence
Population

Keywords

  • Breast cancer
  • Chinese/Caucasian
  • Gene expression profiling
  • MiRNA profiling
  • Race/ethnicity

ASJC Scopus subject areas

  • Oncology
  • Radiology Nuclear Medicine and imaging
  • Cancer Research

Cite this

Molecular portrait of breast cancer in China reveals comprehensive transcriptomic likeness to Caucasian breast cancer and low prevalence of luminal A subtype. / Huang, Xiaoyan; Dugo, Matteo; Callari, Maurizio; Sandri, Marco; De Cecco, Loris; Valeri, Barbara; Carcangiu, Maria Luisa; Xue, Jingyan; Bi, Rui; Veneroni, Silvia; Daidone, Maria Grazia; Ménard, Sylvie; Tagliabue, Elda; Shao, Zhimin; Wu, Jiong; Orlandi, Rosaria.

In: Cancer Medicine, Vol. 4, No. 7, 01.07.2015, p. 1016-1030.

Research output: Contribution to journalArticle

Huang, Xiaoyan ; Dugo, Matteo ; Callari, Maurizio ; Sandri, Marco ; De Cecco, Loris ; Valeri, Barbara ; Carcangiu, Maria Luisa ; Xue, Jingyan ; Bi, Rui ; Veneroni, Silvia ; Daidone, Maria Grazia ; Ménard, Sylvie ; Tagliabue, Elda ; Shao, Zhimin ; Wu, Jiong ; Orlandi, Rosaria. / Molecular portrait of breast cancer in China reveals comprehensive transcriptomic likeness to Caucasian breast cancer and low prevalence of luminal A subtype. In: Cancer Medicine. 2015 ; Vol. 4, No. 7. pp. 1016-1030.
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