TY - JOUR
T1 - Molecular profile of hyalinizing trabecular tumours of the thyroid
T2 - High prevalence of RET/PTC rearrangements and absence of B-raf and N-ras point mutations
AU - Salvatore, Giuliana
AU - Chiappetta, Gennaro
AU - Nikiforov, Yuri E.
AU - Decaussin-Petrucci, Myriam
AU - Fusco, Alfredo
AU - Carney, J. Aidan
AU - Santoro, Massimo
PY - 2005/3
Y1 - 2005/3
N2 - Hyalinizing trabecular tumour (HTT) of the thyroid is a neoplasm of follicular derivation that shares several morphological similarities with papillary thyroid carcinoma (PTC). In this study, we investigated the prevalence of B-raf point mutations, RET/PTC rearrangements and N-ras point mutations in a large HTT series (28 samples). Twenty benign thyroid lesions and 10 PTC served as control cases. A high (47%) prevalence of RET/PTC rearrangements was found in HTT. By contrast, neither B-raf nor N-ras mutations were found in HTT. These findings suggest that, although RET/PTC, N-ras, and B-raf proteins may act along the same signalling cascade, the biological and morphological outcome of their oncogenic activation is not completely overlapping. Thus, in clinical practice, the detection of B-raf mutations in a thyroid follicular tumour may prove to be a valuable tool, supplementing histological examination, and allowing a differential diagnosis between PTC and HTT.
AB - Hyalinizing trabecular tumour (HTT) of the thyroid is a neoplasm of follicular derivation that shares several morphological similarities with papillary thyroid carcinoma (PTC). In this study, we investigated the prevalence of B-raf point mutations, RET/PTC rearrangements and N-ras point mutations in a large HTT series (28 samples). Twenty benign thyroid lesions and 10 PTC served as control cases. A high (47%) prevalence of RET/PTC rearrangements was found in HTT. By contrast, neither B-raf nor N-ras mutations were found in HTT. These findings suggest that, although RET/PTC, N-ras, and B-raf proteins may act along the same signalling cascade, the biological and morphological outcome of their oncogenic activation is not completely overlapping. Thus, in clinical practice, the detection of B-raf mutations in a thyroid follicular tumour may prove to be a valuable tool, supplementing histological examination, and allowing a differential diagnosis between PTC and HTT.
KW - Kinase
KW - Oncogene
KW - Papillary carcinoma
KW - RAF
KW - RET
KW - Thyroid
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U2 - 10.1016/j.ejca.2005.01.004
DO - 10.1016/j.ejca.2005.01.004
M3 - Article
C2 - 15763659
AN - SCOPUS:14844286176
VL - 41
SP - 816
EP - 821
JO - European Journal of Cancer
JF - European Journal of Cancer
SN - 0959-8049
IS - 5
ER -