TY - JOUR
T1 - Molecular profiling of aggressive lymphomas
AU - Rossi, Maura
AU - Laginestra, Maria Antonella
AU - Gazzola, Anna
AU - Sapienza, Maria Rosaria
AU - Pileri, Stefano A.
AU - Piccaluga, Pier Paolo
PY - 2012
Y1 - 2012
N2 - In the last years, several studies of molecular profiling of aggressive lymphomas were performed. In particular, it was shown that DLBCL can be distinguished in two different entities according to GEP. Specifically, ABC and GCB subtypes were characterized by having different pathogenetic and clinical features. In addition, it was demonstrated that DLBCLs are distinct from BL. Indeed, the latter is a unique molecular entity. However, relevant pathological differences emerged among the clinical subtypes. More recently, microRNA profiling provided further information concerning BL-DLBCL distinction as well as for their subclassification. In this paper, the authors based on their own experience and the most updated literature review, the main concept on molecular profiling of aggressive lymphomas.
AB - In the last years, several studies of molecular profiling of aggressive lymphomas were performed. In particular, it was shown that DLBCL can be distinguished in two different entities according to GEP. Specifically, ABC and GCB subtypes were characterized by having different pathogenetic and clinical features. In addition, it was demonstrated that DLBCLs are distinct from BL. Indeed, the latter is a unique molecular entity. However, relevant pathological differences emerged among the clinical subtypes. More recently, microRNA profiling provided further information concerning BL-DLBCL distinction as well as for their subclassification. In this paper, the authors based on their own experience and the most updated literature review, the main concept on molecular profiling of aggressive lymphomas.
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U2 - 10.1155/2012/464680
DO - 10.1155/2012/464680
M3 - Article
C2 - 22190944
AN - SCOPUS:84855586520
VL - 2012
JO - Advances in Hematology
JF - Advances in Hematology
SN - 1687-9104
M1 - 464680
ER -