Molecular profiling of aggressive lymphomas

Maura Rossi, Maria Antonella Laginestra, Anna Gazzola, Maria Rosaria Sapienza, Stefano A. Pileri, Pier Paolo Piccaluga

Research output: Contribution to journalArticlepeer-review


In the last years, several studies of molecular profiling of aggressive lymphomas were performed. In particular, it was shown that DLBCL can be distinguished in two different entities according to GEP. Specifically, ABC and GCB subtypes were characterized by having different pathogenetic and clinical features. In addition, it was demonstrated that DLBCLs are distinct from BL. Indeed, the latter is a unique molecular entity. However, relevant pathological differences emerged among the clinical subtypes. More recently, microRNA profiling provided further information concerning BL-DLBCL distinction as well as for their subclassification. In this paper, the authors based on their own experience and the most updated literature review, the main concept on molecular profiling of aggressive lymphomas.

Original languageEnglish
Article number464680
JournalAdvances in Hematology
Publication statusPublished - 2012

ASJC Scopus subject areas

  • Hematology


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