Molecular profiling of chordoma

Stefanie Scheil-Bertram, Roland Kappler, Alexandra Von Baer, Erich Hartwig, Michael Sarkar, Massimo Serra, Silke Brüderlein, Bettina Westhoff, Ingo Melzner, Birgit Bassaly, Jochen Herms, Heinz Hermann Hugo, Michael Schulte, Peter Möller

Research output: Contribution to journalArticle

26 Citations (Scopus)

Abstract

The molecular basis of chordoma is still poorly understood, particularly with respect to differentially expressed genes involved in the primary origin of chordoma. In this study, therefore, we compared the transcriptional expression profile of one sacral chordoma recurrence, two chordoma cell lines (U-CH1 and U-CH2) and one chondrosarcoma cell line (U-CS2) with vertebral disc using a high-density oligonucleotide array. The expression of 65 genes whose mRNA levels differed significantly (p

Original languageEnglish
Pages (from-to)1041-1055
Number of pages15
JournalInternational Journal of Oncology
Volume44
Issue number4
DOIs
Publication statusPublished - Apr 2014

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Chordoma
Cell Line
Chondrosarcoma
Oligonucleotide Array Sequence Analysis
Gene Expression
Recurrence
Messenger RNA
Genes

Keywords

  • Chondrosarcoma
  • Chordoma
  • Comparative genomic hybridization
  • Fluorescence in situ hybridization
  • GeneChip

ASJC Scopus subject areas

  • Cancer Research
  • Oncology
  • Medicine(all)

Cite this

Scheil-Bertram, S., Kappler, R., Von Baer, A., Hartwig, E., Sarkar, M., Serra, M., ... Möller, P. (2014). Molecular profiling of chordoma. International Journal of Oncology, 44(4), 1041-1055. https://doi.org/10.3892/ijo.2014.2268

Molecular profiling of chordoma. / Scheil-Bertram, Stefanie; Kappler, Roland; Von Baer, Alexandra; Hartwig, Erich; Sarkar, Michael; Serra, Massimo; Brüderlein, Silke; Westhoff, Bettina; Melzner, Ingo; Bassaly, Birgit; Herms, Jochen; Hugo, Heinz Hermann; Schulte, Michael; Möller, Peter.

In: International Journal of Oncology, Vol. 44, No. 4, 04.2014, p. 1041-1055.

Research output: Contribution to journalArticle

Scheil-Bertram, S, Kappler, R, Von Baer, A, Hartwig, E, Sarkar, M, Serra, M, Brüderlein, S, Westhoff, B, Melzner, I, Bassaly, B, Herms, J, Hugo, HH, Schulte, M & Möller, P 2014, 'Molecular profiling of chordoma', International Journal of Oncology, vol. 44, no. 4, pp. 1041-1055. https://doi.org/10.3892/ijo.2014.2268
Scheil-Bertram S, Kappler R, Von Baer A, Hartwig E, Sarkar M, Serra M et al. Molecular profiling of chordoma. International Journal of Oncology. 2014 Apr;44(4):1041-1055. https://doi.org/10.3892/ijo.2014.2268
Scheil-Bertram, Stefanie ; Kappler, Roland ; Von Baer, Alexandra ; Hartwig, Erich ; Sarkar, Michael ; Serra, Massimo ; Brüderlein, Silke ; Westhoff, Bettina ; Melzner, Ingo ; Bassaly, Birgit ; Herms, Jochen ; Hugo, Heinz Hermann ; Schulte, Michael ; Möller, Peter. / Molecular profiling of chordoma. In: International Journal of Oncology. 2014 ; Vol. 44, No. 4. pp. 1041-1055.
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