Molecular profiling of chordoma

Stefanie Scheil-Bertram, Roland Kappler, Alexandra Von Baer, Erich Hartwig, Michael Sarkar, Massimo Serra, Silke Brüderlein, Bettina Westhoff, Ingo Melzner, Birgit Bassaly, Jochen Herms, Heinz Hermann Hugo, Michael Schulte, Peter Möller

Research output: Contribution to journalArticlepeer-review


The molecular basis of chordoma is still poorly understood, particularly with respect to differentially expressed genes involved in the primary origin of chordoma. In this study, therefore, we compared the transcriptional expression profile of one sacral chordoma recurrence, two chordoma cell lines (U-CH1 and U-CH2) and one chondrosarcoma cell line (U-CS2) with vertebral disc using a high-density oligonucleotide array. The expression of 65 genes whose mRNA levels differed significantly (p

Original languageEnglish
Pages (from-to)1041-1055
Number of pages15
JournalInternational Journal of Oncology
Issue number4
Publication statusPublished - Apr 2014


  • Chondrosarcoma
  • Chordoma
  • Comparative genomic hybridization
  • Fluorescence in situ hybridization
  • GeneChip

ASJC Scopus subject areas

  • Cancer Research
  • Oncology
  • Medicine(all)


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