Molecular profiling of chordoma

Stefanie Scheil-Bertram, Roland Kappler, Alexandra Von Baer, Erich Hartwig, Michael Sarkar, Massimo Serra, Silke Brüderlein, Bettina Westhoff, Ingo Melzner, Birgit Bassaly, Jochen Herms, Heinz Hermann Hugo, Michael Schulte, Peter Möller

Research output: Contribution to journalArticlepeer-review

Abstract

The molecular basis of chordoma is still poorly understood, particularly with respect to differentially expressed genes involved in the primary origin of chordoma. In this study, therefore, we compared the transcriptional expression profile of one sacral chordoma recurrence, two chordoma cell lines (U-CH1 and U-CH2) and one chondrosarcoma cell line (U-CS2) with vertebral disc using a high-density oligonucleotide array. The expression of 65 genes whose mRNA levels differed significantly (p

Original languageEnglish
Pages (from-to)1041-1055
Number of pages15
JournalInternational Journal of Oncology
Volume44
Issue number4
DOIs
Publication statusPublished - Apr 2014

Keywords

  • Chondrosarcoma
  • Chordoma
  • Comparative genomic hybridization
  • Fluorescence in situ hybridization
  • GeneChip

ASJC Scopus subject areas

  • Cancer Research
  • Oncology
  • Medicine(all)

Fingerprint Dive into the research topics of 'Molecular profiling of chordoma'. Together they form a unique fingerprint.

Cite this