Molecular profiling of chordoma

Stefanie Scheil-Bertram; Roland Kappler; Alexandra Von Baer; Erich Hartwig; Michael Sarkar; Massimo Serra; Silke Brüderlein; Bettina Westhoff; Ingo Melzner; Birgit Bassaly; Jochen Herms; Heinz Hermann Hugo; Michael Schulte; Peter Möller

doi:10.3892/ijo.2014.2268

Molecular profiling of chordoma

Stefanie Scheil-Bertram, Roland Kappler, Alexandra Von Baer, Erich Hartwig, Michael Sarkar, Massimo Serra, Silke Brüderlein, Bettina Westhoff, Ingo Melzner, Birgit Bassaly, Jochen Herms, Heinz Hermann Hugo, Michael Schulte, Peter Möller

Istituti Ortopedici Rizzoli

Research output: Contribution to journal › Article › peer-review

Abstract

The molecular basis of chordoma is still poorly understood, particularly with respect to differentially expressed genes involved in the primary origin of chordoma. In this study, therefore, we compared the transcriptional expression profile of one sacral chordoma recurrence, two chordoma cell lines (U-CH1 and U-CH2) and one chondrosarcoma cell line (U-CS2) with vertebral disc using a high-density oligonucleotide array. The expression of 65 genes whose mRNA levels differed significantly (p

Original language	English
Pages (from-to)	1041-1055
Number of pages	15
Journal	International Journal of Oncology
Volume	44
Issue number	4
DOIs	https://doi.org/10.3892/ijo.2014.2268
Publication status	Published - Apr 2014

Keywords

Chondrosarcoma
Chordoma
Comparative genomic hybridization
Fluorescence in situ hybridization
GeneChip

ASJC Scopus subject areas

Cancer Research
Oncology
Medicine(all)

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Molecular profiling of chordoma. / Scheil-Bertram, Stefanie; Kappler, Roland; Von Baer, Alexandra; Hartwig, Erich; Sarkar, Michael; Serra, Massimo; Brüderlein, Silke; Westhoff, Bettina; Melzner, Ingo; Bassaly, Birgit; Herms, Jochen; Hugo, Heinz Hermann; Schulte, Michael; Möller, Peter.

In: International Journal of Oncology, Vol. 44, No. 4, 04.2014, p. 1041-1055.

Research output: Contribution to journal › Article › peer-review

Scheil-Bertram, Stefanie ; Kappler, Roland ; Von Baer, Alexandra ; Hartwig, Erich ; Sarkar, Michael ; Serra, Massimo ; Brüderlein, Silke ; Westhoff, Bettina ; Melzner, Ingo ; Bassaly, Birgit ; Herms, Jochen ; Hugo, Heinz Hermann ; Schulte, Michael ; Möller, Peter. / Molecular profiling of chordoma. In: International Journal of Oncology. 2014 ; Vol. 44, No. 4. pp. 1041-1055.

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