Molecular profiling of pancreatic neuroendocrine tumors (pNETS) and the clinical potential

Massimiliano Camilli, Konstantinos Papadimitriou, Amanda Nogueira, Lorena Incorvaia, Antonio Galvano, Federica D’Antonio, Jose Ferri, Daniele Santini, Nicola Silvestris, Antonio Russo, Marc Peeters, Christian Rolfo

Research output: Contribution to journalReview article

Abstract

Introduction: Pancreatic neuroendocrine tumors (pNETs) represent a small part of pancreatic neoplasms, and the knowledge about their indolent clinical course remains a subject of investigation. They occur sporadically or as part of familial cancer syndromes and are classified by WHO in 3 categories. There is ongoing research to understand their molecular profiling and leading mutations. Areas covered: The aim of this review is to clarify the overall aspects of tumorigenesis, to expose the latest developments in understanding the course of the disease and the possible therapeutic implications of these. The review also discusses functional and non-functional pNETs and associated inherited syndromes as well as pNET molecular profiling and its possible guidance in the use of targeted therapy. Expert commentary: In the next decade, a more extensive application of new technologies will help improve quality of life and survival, individualizing treatment protocols and identifying which therapeutic strategy is more suitable for each kind of NET.

Original languageEnglish
Pages (from-to)471-478
Number of pages8
JournalExpert Review of Gastroenterology and Hepatology
Volume12
Issue number5
DOIs
Publication statusPublished - May 4 2018

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Keywords

  • Functional tumors
  • hereditary syndromes
  • molecular pathways
  • neurondocrine tumors
  • pancreatic tumors
  • targeted therapy

ASJC Scopus subject areas

  • Hepatology
  • Gastroenterology

Cite this

Camilli, M., Papadimitriou, K., Nogueira, A., Incorvaia, L., Galvano, A., D’Antonio, F., Ferri, J., Santini, D., Silvestris, N., Russo, A., Peeters, M., & Rolfo, C. (2018). Molecular profiling of pancreatic neuroendocrine tumors (pNETS) and the clinical potential. Expert Review of Gastroenterology and Hepatology, 12(5), 471-478. https://doi.org/10.1080/17474124.2018.1463157