Molecular regulation of cellular immunity by FOXP3

Alicia N. McMurchy, Sara Di Nunzio, Maria Grazia Roncarolo, Rosa Bacchetta, Megan K. Levings

Research output: Chapter in Book/Report/Conference proceedingChapter

15 Citations (Scopus)

Abstract

The immune system is responsible for not only eliminating threats to the body, but also for protecting the body from its own immune responses that would causeharm if left unchecked. Forkhead box protein 3 (FOXP3) is a forkhead family member with an important role in the development and function of a type of CD4+ T cell calledT regulatory cells that is fundamental for maintaining immune tolerance to self. This chapter reviews the structure ofFOXP3 and how its role in the immune systemwasdiscovered. Studies of patients with mutations in FOXP3 who suffer from a syndromeknown asIPEX (immunedysregulation, polyendocrinopathy,enteropathy,x-linked) arealsodiscussed. Investigation into howexpression of FOXP3 is regulatedand howit interactswith other proteins haverecentlyprovided considerable insightinto mechanisms bywhichthe lackof this protein couldcausedisease.Wealsodiscuss how FOXP3isinvolved in the reciprocal development ofT regulatorycells andproinflammatoryT-cells that produce IL-I? A better understandingof how FOXP3 is regulatedand the molecularbasis for its function will ultimatelycontribute to the developmentofT regulatorycell-based cellular therapiesthat could be used to restoredysregulated immune responses.

Original languageEnglish
Title of host publicationAdvances in Experimental Medicine and Biology
Pages30-35
Number of pages6
Volume665
Publication statusPublished - 2009

Publication series

NameAdvances in Experimental Medicine and Biology
Volume665
ISSN (Print)00652598

Fingerprint

Forkhead Transcription Factors
Cellular Immunity
Immune Tolerance
T-cells
Immune system
Regulatory T-Lymphocytes
Immune System
Proteins
Mutation

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Medicine(all)

Cite this

McMurchy, A. N., Di Nunzio, S., Roncarolo, M. G., Bacchetta, R., & Levings, M. K. (2009). Molecular regulation of cellular immunity by FOXP3. In Advances in Experimental Medicine and Biology (Vol. 665, pp. 30-35). (Advances in Experimental Medicine and Biology; Vol. 665).

Molecular regulation of cellular immunity by FOXP3. / McMurchy, Alicia N.; Di Nunzio, Sara; Roncarolo, Maria Grazia; Bacchetta, Rosa; Levings, Megan K.

Advances in Experimental Medicine and Biology. Vol. 665 2009. p. 30-35 (Advances in Experimental Medicine and Biology; Vol. 665).

Research output: Chapter in Book/Report/Conference proceedingChapter

McMurchy, AN, Di Nunzio, S, Roncarolo, MG, Bacchetta, R & Levings, MK 2009, Molecular regulation of cellular immunity by FOXP3. in Advances in Experimental Medicine and Biology. vol. 665, Advances in Experimental Medicine and Biology, vol. 665, pp. 30-35.
McMurchy AN, Di Nunzio S, Roncarolo MG, Bacchetta R, Levings MK. Molecular regulation of cellular immunity by FOXP3. In Advances in Experimental Medicine and Biology. Vol. 665. 2009. p. 30-35. (Advances in Experimental Medicine and Biology).
McMurchy, Alicia N. ; Di Nunzio, Sara ; Roncarolo, Maria Grazia ; Bacchetta, Rosa ; Levings, Megan K. / Molecular regulation of cellular immunity by FOXP3. Advances in Experimental Medicine and Biology. Vol. 665 2009. pp. 30-35 (Advances in Experimental Medicine and Biology).
@inbook{016c0c23ed3149aca81f33ebb666d5f5,
title = "Molecular regulation of cellular immunity by FOXP3",
abstract = "The immune system is responsible for not only eliminating threats to the body, but also for protecting the body from its own immune responses that would causeharm if left unchecked. Forkhead box protein 3 (FOXP3) is a forkhead family member with an important role in the development and function of a type of CD4+ T cell calledT regulatory cells that is fundamental for maintaining immune tolerance to self. This chapter reviews the structure ofFOXP3 and how its role in the immune systemwasdiscovered. Studies of patients with mutations in FOXP3 who suffer from a syndromeknown asIPEX (immunedysregulation, polyendocrinopathy,enteropathy,x-linked) arealsodiscussed. Investigation into howexpression of FOXP3 is regulatedand howit interactswith other proteins haverecentlyprovided considerable insightinto mechanisms bywhichthe lackof this protein couldcausedisease.Wealsodiscuss how FOXP3isinvolved in the reciprocal development ofT regulatorycells andproinflammatoryT-cells that produce IL-I? A better understandingof how FOXP3 is regulatedand the molecularbasis for its function will ultimatelycontribute to the developmentofT regulatorycell-based cellular therapiesthat could be used to restoredysregulated immune responses.",
author = "McMurchy, {Alicia N.} and {Di Nunzio}, Sara and Roncarolo, {Maria Grazia} and Rosa Bacchetta and Levings, {Megan K.}",
year = "2009",
language = "English",
isbn = "9781441915986",
volume = "665",
series = "Advances in Experimental Medicine and Biology",
pages = "30--35",
booktitle = "Advances in Experimental Medicine and Biology",

}

TY - CHAP

T1 - Molecular regulation of cellular immunity by FOXP3

AU - McMurchy, Alicia N.

AU - Di Nunzio, Sara

AU - Roncarolo, Maria Grazia

AU - Bacchetta, Rosa

AU - Levings, Megan K.

PY - 2009

Y1 - 2009

N2 - The immune system is responsible for not only eliminating threats to the body, but also for protecting the body from its own immune responses that would causeharm if left unchecked. Forkhead box protein 3 (FOXP3) is a forkhead family member with an important role in the development and function of a type of CD4+ T cell calledT regulatory cells that is fundamental for maintaining immune tolerance to self. This chapter reviews the structure ofFOXP3 and how its role in the immune systemwasdiscovered. Studies of patients with mutations in FOXP3 who suffer from a syndromeknown asIPEX (immunedysregulation, polyendocrinopathy,enteropathy,x-linked) arealsodiscussed. Investigation into howexpression of FOXP3 is regulatedand howit interactswith other proteins haverecentlyprovided considerable insightinto mechanisms bywhichthe lackof this protein couldcausedisease.Wealsodiscuss how FOXP3isinvolved in the reciprocal development ofT regulatorycells andproinflammatoryT-cells that produce IL-I? A better understandingof how FOXP3 is regulatedand the molecularbasis for its function will ultimatelycontribute to the developmentofT regulatorycell-based cellular therapiesthat could be used to restoredysregulated immune responses.

AB - The immune system is responsible for not only eliminating threats to the body, but also for protecting the body from its own immune responses that would causeharm if left unchecked. Forkhead box protein 3 (FOXP3) is a forkhead family member with an important role in the development and function of a type of CD4+ T cell calledT regulatory cells that is fundamental for maintaining immune tolerance to self. This chapter reviews the structure ofFOXP3 and how its role in the immune systemwasdiscovered. Studies of patients with mutations in FOXP3 who suffer from a syndromeknown asIPEX (immunedysregulation, polyendocrinopathy,enteropathy,x-linked) arealsodiscussed. Investigation into howexpression of FOXP3 is regulatedand howit interactswith other proteins haverecentlyprovided considerable insightinto mechanisms bywhichthe lackof this protein couldcausedisease.Wealsodiscuss how FOXP3isinvolved in the reciprocal development ofT regulatorycells andproinflammatoryT-cells that produce IL-I? A better understandingof how FOXP3 is regulatedand the molecularbasis for its function will ultimatelycontribute to the developmentofT regulatorycell-based cellular therapiesthat could be used to restoredysregulated immune responses.

UR - http://www.scopus.com/inward/record.url?scp=77952500003&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=77952500003&partnerID=8YFLogxK

M3 - Chapter

SN - 9781441915986

VL - 665

T3 - Advances in Experimental Medicine and Biology

SP - 30

EP - 35

BT - Advances in Experimental Medicine and Biology

ER -