TY - JOUR
T1 - Molecular remission after allogeneic or autologou8 transplantation of hematopoietic stem cells for multiple myeloma
AU - Martinelli, Giovanni G.
AU - Terragna, Carolina C.
AU - Zamagni, Elena E.
AU - Ronconi, Sonia S.
AU - Tosi, Patrizia P.
AU - Lemoli, Roberto Massimco R M
AU - Bandini, Giuseppe G.
AU - Motta, Maria Rosa M R
AU - Testoni, Nicoletts N.
AU - Amabile, Marilina M.
AU - Ottaviani, Emanuela E.
AU - Vianelli, Nicola Nj
AU - De Vivo, Antonio A.
AU - Gozzetti, Alessandro A.
AU - Turamichèle M Cavo, Santé S.
PY - 2000
Y1 - 2000
N2 - To assess clinical relevance of minimal residual disease (MRD) in patients withj multiple myeloma (MM), 50 patients were monitored in complete clinical remission (CCR) after autologous or allogeneic stem cell transplantation. Stringent molecular monitoring using clonal markers based upon rearranged! immunoglobulin heavy-chain genes was done in 44/50 MM patients in CCR. Molecular! remission (MCR) was defined as 1 consecutive negative PCR results. 12/44 (27%) molecularly monitored patients achieved MCR; 4/12 turned PCR+ and 1 /4 relapsed. Patients achieving MCR had a significantly lower relapse rate (16% vs. 41% ; I p
AB - To assess clinical relevance of minimal residual disease (MRD) in patients withj multiple myeloma (MM), 50 patients were monitored in complete clinical remission (CCR) after autologous or allogeneic stem cell transplantation. Stringent molecular monitoring using clonal markers based upon rearranged! immunoglobulin heavy-chain genes was done in 44/50 MM patients in CCR. Molecular! remission (MCR) was defined as 1 consecutive negative PCR results. 12/44 (27%) molecularly monitored patients achieved MCR; 4/12 turned PCR+ and 1 /4 relapsed. Patients achieving MCR had a significantly lower relapse rate (16% vs. 41% ; I p
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M3 - Article
AN - SCOPUS:33748651017
VL - 96
JO - Blood
JF - Blood
SN - 0006-4971
IS - 11 PART I
ER -