Molecular signaling blockade as a new approach to inhibit leukocyte-endothelial interactions for inflammatory bowel disease treatment

Franco Scaldaferri, Carmen Correale, Antonio Gasbarrini, Silvio Danese

Research output: Contribution to journalArticlepeer-review

Abstract

Mitogen-activated protein kinases (MAPK) are among the major widespread transduction pathways in humans. They are involved in several inflammatory disorders, including the pathogenesis of inflammatory bowel disease (IBD). A recent paper showed that activated MAPK are upregulated on endothelium and fibroblasts from intestinal biopsies of active IBD patients. In vitro experiments demonstrated that MAPK activation on intestinal endothelial cells and fibroblasts are responsible for the production of certain chemokines, increased leukocyte adhesion and transmigration. Specific local inhibition of MAPK activity on endothelial cells and fibroblasts may provide a new mechanism to control mucosal inflammation and leukocyte recruitment into the intestine of active IBD patients.

Original languageEnglish
Pages (from-to)296-299
Number of pages4
JournalCell Adhesion and Migration
Volume3
Issue number3
Publication statusPublished - Jul 2009

Keywords

  • Inflammation
  • Inflammatory bowel disease
  • Intestinal mucosal endothelium
  • Intestinal mucosal fibroblasts
  • Leukocytes adhesion and migration
  • MAPK
  • MAPK inhibitors

ASJC Scopus subject areas

  • Cell Biology
  • Cellular and Molecular Neuroscience

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