Molecular signature in HCV-positive lymphomas

Valli De Re, Laura Caggiari, Marica Garziera, Mariangela De Zorzi, Ombretta Repetto

Research output: Contribution to journalArticlepeer-review

Abstract

Hepatitis C virus (HCV) is a positive, single-stranded RNA virus, which has been associated to different subtypes of B-cell non-Hodgkin lymphoma (B-NHL). Cumulative evidence suggests an HCV-related antigen driven process in the B-NHL development. The underlying molecular signature associated to HCV-related B-NHL has to date remained obscure. In this review, we discuss the recent developments in this field with a special mention to different sets of genes whose expression is associated with BCR coupled to Blys signaling which in turn was found to be linked to B-cell maturation stages and NF-κb transcription factor. Even if recent progress on HCV-B-NHL signature has been made, the precise relationship between HCV and lymphoma development and phenotype signature remain to be clarified.

Original languageEnglish
Article number623465
JournalClinical and Developmental Immunology
Volume2012
DOIs
Publication statusPublished - 2012

ASJC Scopus subject areas

  • Immunology
  • Immunology and Allergy
  • Medicine(all)

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