Abstract
The insulin-like growth factor (IGF) system, which is constituted by the IGF-1 and IGF-2 peptide hormones, their corresponding receptors and several IGF binding proteins, is involved in physiological and pathophysiological processes. The IGF system promotes cancer proliferation/survival and its signaling induces the epithelial-mesenchymal transition (EMT) phenotype, which contributes to the migration, invasiveness, and metastasis of epithelial tumors. These cancers share two major IGF-1R signaling transduction pathways, PI3K/AKT and RAS/MEK/ERK. However, as far as we could review at this time, each type of cancer cell undergoes EMT through tumor-specific routes. Here, we review the tumor-specific molecular signatures of IGF-1-mediated EMT in breast, lung, and gastric cancers.
| Original language | English |
|---|---|
| Article number | 2411 |
| Journal | International Journal of Molecular Sciences |
| Volume | 19 |
| Issue number | 8 |
| DOIs | |
| Publication status | Published - Aug 15 2018 |
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Keywords
- Cancer
- Epithelial-mesenchymal transition (EMT)
- IGF-1 receptor (IGF-1R)
- Insulin-like growth factor 1 (IGF-1)
- Metastasis
- PI3K/AKT pathway
- RAS/MEK/ERK pathway
ASJC Scopus subject areas
- Catalysis
- Molecular Biology
- Spectroscopy
- Computer Science Applications
- Physical and Theoretical Chemistry
- Organic Chemistry
- Inorganic Chemistry
Cite this
Molecular signatures of the insulin-like growth factor 1-mediated epithelial-mesenchymal transition in breast, lung and gastric cancers. / Cevenini, Armando; Orrù, Stefania; Mancini, Annamaria; Alfieri, Andreina; Buono, Pasqualina; Imperlini, Esther.
In: International Journal of Molecular Sciences, Vol. 19, No. 8, 2411, 15.08.2018.Research output: Contribution to journal › Review article
}
TY - JOUR
T1 - Molecular signatures of the insulin-like growth factor 1-mediated epithelial-mesenchymal transition in breast, lung and gastric cancers
AU - Cevenini, Armando
AU - Orrù, Stefania
AU - Mancini, Annamaria
AU - Alfieri, Andreina
AU - Buono, Pasqualina
AU - Imperlini, Esther
PY - 2018/8/15
Y1 - 2018/8/15
N2 - The insulin-like growth factor (IGF) system, which is constituted by the IGF-1 and IGF-2 peptide hormones, their corresponding receptors and several IGF binding proteins, is involved in physiological and pathophysiological processes. The IGF system promotes cancer proliferation/survival and its signaling induces the epithelial-mesenchymal transition (EMT) phenotype, which contributes to the migration, invasiveness, and metastasis of epithelial tumors. These cancers share two major IGF-1R signaling transduction pathways, PI3K/AKT and RAS/MEK/ERK. However, as far as we could review at this time, each type of cancer cell undergoes EMT through tumor-specific routes. Here, we review the tumor-specific molecular signatures of IGF-1-mediated EMT in breast, lung, and gastric cancers.
AB - The insulin-like growth factor (IGF) system, which is constituted by the IGF-1 and IGF-2 peptide hormones, their corresponding receptors and several IGF binding proteins, is involved in physiological and pathophysiological processes. The IGF system promotes cancer proliferation/survival and its signaling induces the epithelial-mesenchymal transition (EMT) phenotype, which contributes to the migration, invasiveness, and metastasis of epithelial tumors. These cancers share two major IGF-1R signaling transduction pathways, PI3K/AKT and RAS/MEK/ERK. However, as far as we could review at this time, each type of cancer cell undergoes EMT through tumor-specific routes. Here, we review the tumor-specific molecular signatures of IGF-1-mediated EMT in breast, lung, and gastric cancers.
KW - Cancer
KW - Epithelial-mesenchymal transition (EMT)
KW - IGF-1 receptor (IGF-1R)
KW - Insulin-like growth factor 1 (IGF-1)
KW - Metastasis
KW - PI3K/AKT pathway
KW - RAS/MEK/ERK pathway
UR - http://www.scopus.com/inward/record.url?scp=85052159487&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85052159487&partnerID=8YFLogxK
U2 - 10.3390/ijms19082411
DO - 10.3390/ijms19082411
M3 - Review article
C2 - 30111747
AN - SCOPUS:85052159487
VL - 19
JO - International Journal of Molecular Sciences
JF - International Journal of Molecular Sciences
SN - 1661-6596
IS - 8
M1 - 2411
ER -