Molecular technology and the recombinant TSH have changed diagnostics of thyroid carcinoma with positive I-131 whole body scan but low serum thyroglobulin

Liliana Montella, Michele Caraglia, Alberto Abbruzzese, Andrea Soricelli, Salvatore Del Prete, Giovanni Squame, Marco Salvatore

Research output: Contribution to journalArticle

Abstract

The early detection of recurrent differentiated thyroid carcinoma (DTC) cells in the post surgery DTC patients relies on the sensitivity of measuring both the level of thyroglobulin (Tg) and 131-Iodine distribution by Whole Body Scan (WBS). Undetectable level of Tg associated with negative WBS or elevated levels of Tg associated with positive WBS ("concordant") is ordinarily indicative of either absence or presence of disease. At times, elevated level of Tg with negative WBS or low levels of Tg with positive WBS ("discordant") could also occur. In the present study, we retrospectively reviewed series of 573 patients with DTC followed in the Diagnostic Imaging and Radiotherapy of the University "Federico II" of Naples between 1993 and 1997. We focused on 9 out of 573 patients (1.56%) who had a discordant pattern with low level of Tg/positive WBS in the post-surgical follow-up. Four patients were metastatic at presentation while 5 patients with metastasis during follow-up still remained in persistently low levels of Tg (

Original languageEnglish
Pages (from-to)268-273
Number of pages6
JournalExperimental and Molecular Medicine
Volume36
Issue number3
Publication statusPublished - Jun 30 2004

Keywords

  • Differentiated thyroid carcinoma
  • Follow-up
  • Thyroglobulin
  • Whole body scan

ASJC Scopus subject areas

  • Biochemistry
  • Genetics

Fingerprint Dive into the research topics of 'Molecular technology and the recombinant TSH have changed diagnostics of thyroid carcinoma with positive I-131 whole body scan but low serum thyroglobulin'. Together they form a unique fingerprint.

  • Cite this