Abstract
Much evidence in the last few years suggests that the antiproliferative effects of various garlic secondary metabolites in in vitro experimental systems are due to redox-based mechanisms. In particular, sulfur-containing allyl compounds have been demonstrated to generate reactive oxygen species and to modify directly the redox state of specific reactive cysteines on protein surfaces. On the basis of such properties, allyl compounds, in particular the ones present in the oil-soluble fraction of garlic extracts, can function as modulators of several redox-mediated signaling pathways related to the activation of mitogen-activated protein kinases, cell cycle, DNA repair, and cell demise. However, even though many in vitro studies have tried to dissect the mechanisms of action of garlic derivatives, research in this field is still incomplete and questions about bioavailability, biotransformation, and pro-oxidant activity are still unanswered. This review discusses recent findings on such aspects, focusing on the chemistry of allyl compounds and their preferential cellular targets as well as on related nutritional aspects.
| Original language | English |
|---|---|
| Pages (from-to) | 2053-2057 |
| Number of pages | 5 |
| Journal | Journal of Nutrition |
| Volume | 138 |
| Issue number | 11 |
| Publication status | Published - Nov 2008 |
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ASJC Scopus subject areas
- Medicine (miscellaneous)
- Nutrition and Dietetics
Cite this
Molecular transduction mechanisms of the redox network underlying the antiproliferative effects of allyl compounds from garlic. / Filomeni, Giuseppe; Rotilio, Giuseppe; Ciriolo, Maria R.
In: Journal of Nutrition, Vol. 138, No. 11, 11.2008, p. 2053-2057.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Molecular transduction mechanisms of the redox network underlying the antiproliferative effects of allyl compounds from garlic
AU - Filomeni, Giuseppe
AU - Rotilio, Giuseppe
AU - Ciriolo, Maria R.
PY - 2008/11
Y1 - 2008/11
N2 - Much evidence in the last few years suggests that the antiproliferative effects of various garlic secondary metabolites in in vitro experimental systems are due to redox-based mechanisms. In particular, sulfur-containing allyl compounds have been demonstrated to generate reactive oxygen species and to modify directly the redox state of specific reactive cysteines on protein surfaces. On the basis of such properties, allyl compounds, in particular the ones present in the oil-soluble fraction of garlic extracts, can function as modulators of several redox-mediated signaling pathways related to the activation of mitogen-activated protein kinases, cell cycle, DNA repair, and cell demise. However, even though many in vitro studies have tried to dissect the mechanisms of action of garlic derivatives, research in this field is still incomplete and questions about bioavailability, biotransformation, and pro-oxidant activity are still unanswered. This review discusses recent findings on such aspects, focusing on the chemistry of allyl compounds and their preferential cellular targets as well as on related nutritional aspects.
AB - Much evidence in the last few years suggests that the antiproliferative effects of various garlic secondary metabolites in in vitro experimental systems are due to redox-based mechanisms. In particular, sulfur-containing allyl compounds have been demonstrated to generate reactive oxygen species and to modify directly the redox state of specific reactive cysteines on protein surfaces. On the basis of such properties, allyl compounds, in particular the ones present in the oil-soluble fraction of garlic extracts, can function as modulators of several redox-mediated signaling pathways related to the activation of mitogen-activated protein kinases, cell cycle, DNA repair, and cell demise. However, even though many in vitro studies have tried to dissect the mechanisms of action of garlic derivatives, research in this field is still incomplete and questions about bioavailability, biotransformation, and pro-oxidant activity are still unanswered. This review discusses recent findings on such aspects, focusing on the chemistry of allyl compounds and their preferential cellular targets as well as on related nutritional aspects.
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UR - http://www.scopus.com/inward/citedby.url?scp=55949084077&partnerID=8YFLogxK
M3 - Article
C2 - 18936196
AN - SCOPUS:55949084077
VL - 138
SP - 2053
EP - 2057
JO - Journal of Nutrition
JF - Journal of Nutrition
SN - 0022-3166
IS - 11
ER -