Molecular variation of human HSP90alpha and HSP90beta genes in Caucasians.

Giuseppe Passarino, Gianpiero L. Cavalleri, Rosalia Stecconi, Claudio Franceschi, Katia Altomare, Serena Dato, Valentina Greco, L. Luca Cavalli Sforza, Peter A. Underhill, Giovanna de Benedictis

Research output: Contribution to journalArticlepeer-review


Understanding DNA variation within the human genome is fundamental to the identification and interpretation of genetic components underlying complex traits and diseases. Despite their role in many crucial cellular pathways and their reported involvement in many complex diseases no data are available on the molecular variability of the genes coding for Heat Shock Proteins 90Kda (HSP90). Towards this purpose we have used DHPLC methodology to survey, a sample of Caucasians for genetic polymorphisms in the exons and exon-flanking regions of the expressed genes of human HSP90 gene families, HSP90alpha (HSPCAL4, 14q31.3) and HSP90beta (HSPCB, 6p12). A total of 18 and 11 variants were found in the HSP90-alpha and -beta genes respectively, providing an initial view of human genetic variation in these important genes. Only three of the observed mutations altered the genic product. Interestingly, one of the variations observed was a missense mutation leading to the impairment of the hsp90alpha protein.

Original languageEnglish
Pages (from-to)554-555
Number of pages2
JournalHuman Mutation
Issue number5
Publication statusPublished - May 2003

ASJC Scopus subject areas

  • Genetics
  • Genetics(clinical)


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