Monitoring brain tissue oxygen tension in brain-injured patients reveals hypoxic episodes in normal-appearing and in peri-focal tissue

Luca Longhi, Francesca Pagan, Valerio Valeriani, Sandra Magnoni, Elisa R. Zanier, Valeria Conte, Vincenzo Branca, Nino Stocchetti

Research output: Contribution to journalArticlepeer-review

Abstract

Objective: We compared brain tissue oxygen tension (PtiO2) measured in peri-focal and in normal-appearing brain parenchyma on computerized tomography (CT) in patients following traumatic brain injury (TBI). Design: Prospective observational study. Setting: Neurointensive care unit. Patients and participants: Thirty-two consecutive TBI patients were subjected to PtiO 2 monitoring. Interventions: Peri-focal tissue was identified by the presence of a hypodense area of the contusion and/or within 1 cm from the core of the contusion. The position of the tip of the PtiO2 probe was assessed at follow-up CT scan. Measurements and results: Mean PtiO2 in the peri-contusional tissue was 19.7 ± 2.1 mmHg and was lower than PtiO2 in normal-appearing tissue (25.5 ± 1.5 mmHg, p <0.05), despite a greater cerebral perfusion pressure (CPP) (73.7 ± 2.3 mmHg vs. 67.4 ± 1.4 mmHg, p <0.05). We observed both in peri-focal tissue and in normal-appearing tissue episodes of brain hypoxia (PtiO 2 <20 mmHg for at least 10 min), whose median duration was longer in peri-focal tissue than in normal-appearing tissue (51% vs. 34% of monitoring time, p <0.01). In peri-focal tissue, we observed a progressive PtiO 2 increase from pathologic to normal values (p <0.01). Conclusions: Multiple episodes of brain hypoxia occurred over the first 5 days following severe TBI. PtiO2 was lower in peri-contusional tissue than in normal-appearing tissue. In peri-contusional tissue, a progressive increase of PtiO2 from pathologic to normal values was observed over time, suggestive of an improvement at microcirculatory level.

Original languageEnglish
Pages (from-to)2136-2142
Number of pages7
JournalIntensive Care Medicine
Volume33
Issue number12
DOIs
Publication statusPublished - Dec 2007

Keywords

  • Brain hypoxia
  • Brain oxygenation
  • Pathophysiology
  • PtiO
  • Secondary insults
  • Traumatic brain injury

ASJC Scopus subject areas

  • Critical Care and Intensive Care Medicine

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