Monitoring cytochrome P-450 activity during rabeprazole treatment in patients with gastresophageal reflux disease

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Abstract

Proton pump inhibitors (PPIs) are the cornerstone in the treatment of gastresophageal reflux disease (GORD). PPIs are metabolized by the hepatic cytochrome P-450 enzymes (CYP-450). Rabeprazole is a PPI whose metabolism shows fewer interactions compared to other PPIs. In this study we evaluated the influence of rabeprazole administration on hepatic CYP-450 activity as measured by the 13C-aminopyrine breath test (13C-ABT) in a group of patients with GORD. 13C-ABT was performed on five GORD patients both before and after 1 week of rabeprazole administration (20 mg, b.i.d.). Pretreatment 13C-ABT results were compared to posttreatment results. Pre- and posttreatment 13C-ABT results for patients were compared to those obtained in five controls who did the test twice, with a 1-week interval in between. Before treatment, the 13C-ABT results for the GORD patients did not significantly differ from those of healthy subjects. After treatment, we observed no significant modification of the 13C-ABT in GORD patients compared to pretreatment values (13C-ABT %dose/hr, 10.56±1.31 versus 11.17±0.88; 13C-ABT %cumulative dose, 8.08±1.11 versus 8.34±0.56). Posttreatment 13C-ABT results were not significantly different from those obtained in controls at weekly repetition of the test. In patients with GORD, 1-week, full-dose rabeprazole does not display any significant interactions with CYP-450 activity.

Original languageEnglish
Pages (from-to)1602-1606
Number of pages5
JournalDigestive Diseases and Sciences
Volume51
Issue number9
DOIs
Publication statusPublished - Sep 2006

Keywords

  • C-aminopyrine breath test
  • Liver function
  • Rabeprazole

ASJC Scopus subject areas

  • Gastroenterology

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