Monitoring of human cytomegalovirus DNAemia during primary infection in transmitter and non-transmitter mothers

Maurizio Zavattoni, Milena Furione, Paolo Lanzarini, Alessia Arossa, Mariangela Rustico, Beatrice Tassis, Antonio Piralla, Fausto Baldanti

Research output: Contribution to journalArticle

Abstract

Background and objectives It has been reported that maternal DNAemia is detectable in three quarters of pregnant women with acute/recent primary HCMV infections, with a higher median number of HCMV DNA copies/ml blood in transmitter as compared with non-transmitter mothers. Study design The kinetics of HCMV DNA in blood of transmitter vs non-transmitter pregnant women with primary HCMV infection was retrospectively analyzed from their first blood sampling at referral up to amniocentesis strictly performed at 19–21 weeks’ gestation. Monthly monitoring of maternal HCMV DNAemia was performed up to prenatal diagnosis. Results HCMV DNAemia was determined in 154 pregnant women. At amniocentesis, HCMV DNA in blood was positive in 42/50 (84.0%) amniotic fluid (AF) −positive and 21/104 (20.2%) AF-negative mothers (p 

Original languageEnglish
Pages (from-to)89-93
Number of pages5
JournalJournal of Clinical Virology
Volume82
DOIs
Publication statusPublished - Sep 1 2016

Keywords

  • HCMV congenital infection
  • Maternal DNAemia
  • Prognostic value

ASJC Scopus subject areas

  • Medicine(all)
  • Virology
  • Infectious Diseases

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