The development of specific and sensitive methods to measure plasma levels of anticonvulsant drugs in man has allowed the accumulation of a considerable number of analytical data and the calculation of the most relevant kinetic parameters of the most used drugs in the treatment of epilepsy. It should be stressed, however, that these kinetic data are subjected to large variations depending upon a number of variables. Among such variables, age appears to be an important factor for the number of anticonvulsant agents. By combining the work of several laboratories, it has also been possible to establish for most of the drugs at which plasma level range therapeutical effects occur without the presence of undue side effects. These therapeutic ranges may represent a useful point of reference for the clinician in deciding whether a lack of therapeutic response or in the presence of toxic effects may be attributed to an inadequate dose or schedule of treatment of the drug. It should be recalled here that practically, it is impossible to predict for most of the drugs (phenobarbital, diphenylhydantoin, ethosuccimide, carbamazepine, n dipropyl acetate, clonazepam) the plasma level present for a given patient as a function of the administered dose.
|Number of pages||2|
|Publication status||Published - 1976|
ASJC Scopus subject areas
- Organic Chemistry
- Drug Discovery