Monitoring of plasma levels in epileptic patients

S. Garattini, P. L. Morselli

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

The development of specific and sensitive methods to measure plasma levels of anticonvulsant drugs in man has allowed the accumulation of a considerable number of analytical data and the calculation of the most relevant kinetic parameters of the most used drugs in the treatment of epilepsy. It should be stressed, however, that these kinetic data are subjected to large variations depending upon a number of variables. Among such variables, age appears to be an important factor for the number of anticonvulsant agents. By combining the work of several laboratories, it has also been possible to establish for most of the drugs at which plasma level range therapeutical effects occur without the presence of undue side effects. These therapeutic ranges may represent a useful point of reference for the clinician in deciding whether a lack of therapeutic response or in the presence of toxic effects may be attributed to an inadequate dose or schedule of treatment of the drug. It should be recalled here that practically, it is impossible to predict for most of the drugs (phenobarbital, diphenylhydantoin, ethosuccimide, carbamazepine, n dipropyl acetate, clonazepam) the plasma level present for a given patient as a function of the administered dose.

Original languageEnglish
Pages (from-to)1258-1259
Number of pages2
JournalArzneimittel-Forschung/Drug Research
Volume26
Issue number6
Publication statusPublished - 1976

Fingerprint

Plasmas
Monitoring
Pharmaceutical Preparations
Anticonvulsants
Clonazepam
Poisons
Carbamazepine
Valproic Acid
Phenytoin
Therapeutics
Phenobarbital
Kinetic parameters
Epilepsy
Appointments and Schedules
Kinetics

ASJC Scopus subject areas

  • Chemistry(all)
  • Organic Chemistry
  • Drug Discovery
  • Pharmacology

Cite this

Monitoring of plasma levels in epileptic patients. / Garattini, S.; Morselli, P. L.

In: Arzneimittel-Forschung/Drug Research, Vol. 26, No. 6, 1976, p. 1258-1259.

Research output: Contribution to journalArticle

Garattini, S. ; Morselli, P. L. / Monitoring of plasma levels in epileptic patients. In: Arzneimittel-Forschung/Drug Research. 1976 ; Vol. 26, No. 6. pp. 1258-1259.
@article{939ef632f1d74bdab362b3526fecefcd,
title = "Monitoring of plasma levels in epileptic patients",
abstract = "The development of specific and sensitive methods to measure plasma levels of anticonvulsant drugs in man has allowed the accumulation of a considerable number of analytical data and the calculation of the most relevant kinetic parameters of the most used drugs in the treatment of epilepsy. It should be stressed, however, that these kinetic data are subjected to large variations depending upon a number of variables. Among such variables, age appears to be an important factor for the number of anticonvulsant agents. By combining the work of several laboratories, it has also been possible to establish for most of the drugs at which plasma level range therapeutical effects occur without the presence of undue side effects. These therapeutic ranges may represent a useful point of reference for the clinician in deciding whether a lack of therapeutic response or in the presence of toxic effects may be attributed to an inadequate dose or schedule of treatment of the drug. It should be recalled here that practically, it is impossible to predict for most of the drugs (phenobarbital, diphenylhydantoin, ethosuccimide, carbamazepine, n dipropyl acetate, clonazepam) the plasma level present for a given patient as a function of the administered dose.",
author = "S. Garattini and Morselli, {P. L.}",
year = "1976",
language = "English",
volume = "26",
pages = "1258--1259",
journal = "Arzneimittel-Forschung/Drug Research",
issn = "0004-4172",
publisher = "Editio Cantor Verlag GmbH",
number = "6",

}

TY - JOUR

T1 - Monitoring of plasma levels in epileptic patients

AU - Garattini, S.

AU - Morselli, P. L.

PY - 1976

Y1 - 1976

N2 - The development of specific and sensitive methods to measure plasma levels of anticonvulsant drugs in man has allowed the accumulation of a considerable number of analytical data and the calculation of the most relevant kinetic parameters of the most used drugs in the treatment of epilepsy. It should be stressed, however, that these kinetic data are subjected to large variations depending upon a number of variables. Among such variables, age appears to be an important factor for the number of anticonvulsant agents. By combining the work of several laboratories, it has also been possible to establish for most of the drugs at which plasma level range therapeutical effects occur without the presence of undue side effects. These therapeutic ranges may represent a useful point of reference for the clinician in deciding whether a lack of therapeutic response or in the presence of toxic effects may be attributed to an inadequate dose or schedule of treatment of the drug. It should be recalled here that practically, it is impossible to predict for most of the drugs (phenobarbital, diphenylhydantoin, ethosuccimide, carbamazepine, n dipropyl acetate, clonazepam) the plasma level present for a given patient as a function of the administered dose.

AB - The development of specific and sensitive methods to measure plasma levels of anticonvulsant drugs in man has allowed the accumulation of a considerable number of analytical data and the calculation of the most relevant kinetic parameters of the most used drugs in the treatment of epilepsy. It should be stressed, however, that these kinetic data are subjected to large variations depending upon a number of variables. Among such variables, age appears to be an important factor for the number of anticonvulsant agents. By combining the work of several laboratories, it has also been possible to establish for most of the drugs at which plasma level range therapeutical effects occur without the presence of undue side effects. These therapeutic ranges may represent a useful point of reference for the clinician in deciding whether a lack of therapeutic response or in the presence of toxic effects may be attributed to an inadequate dose or schedule of treatment of the drug. It should be recalled here that practically, it is impossible to predict for most of the drugs (phenobarbital, diphenylhydantoin, ethosuccimide, carbamazepine, n dipropyl acetate, clonazepam) the plasma level present for a given patient as a function of the administered dose.

UR - http://www.scopus.com/inward/record.url?scp=0017164132&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0017164132&partnerID=8YFLogxK

M3 - Article

VL - 26

SP - 1258

EP - 1259

JO - Arzneimittel-Forschung/Drug Research

JF - Arzneimittel-Forschung/Drug Research

SN - 0004-4172

IS - 6

ER -