Monitoraggio dei livelli sierici di sE-selectina in corso di terapia in tre differenti dermatosi.

Translated title of the contribution: Monitoring of sE-selectin serum levels in three different dermatoses

L. D'Auria, C. Bonifati, A. Mussi, F. Ameglio

Research output: Contribution to journalArticlepeer-review

Abstract

PURPOSE: To determine the behaviour of serum levels of soluble E-selectin (sE-selectin), the soluble isoform of E-selectin, before/during/after therapy in patients with three. PATIENTS AND METHODS: Using commercially available ELISA kits, serum levels of sE-selectin have been determined in 15 patients with psoriasis, 15 with pemphigus vulgaris and 15 with bullous pemphigoid, and compared with those of 30 healthy subjects. RESULTS: The results showed increased serum levels of sE-selectin in the three groups of patients as compared with those of 30 healthy subjects (p <0.01). In addition, serum levels were significantly correlated with the disease activity expressed as Psoriasis Area and Severity Index (PASI score) (R = 0.56, p = 0.014) in psoriasis, and as number of the visible lesions (blisters/erosions), in the two bullous dermatoses (R = 0.81, p <0.01). After therapy, the marker levels were significantly decreased (p <0.01). CONCLUSIONS: Overall, these data suggest that serum determinations of sE-selectin could represent a clinically useful indicator to monitor therapy.

Translated title of the contributionMonitoring of sE-selectin serum levels in three different dermatoses
Original languageItalian
Pages (from-to)49-52
Number of pages4
JournalClinica Terapeutica
Volume149
Issue number921
Publication statusPublished - Jan 1998

ASJC Scopus subject areas

  • Medicine(all)

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